Clinical Response and Homocysteine Reduction Using Reduced B-Vitamin Therapy in MTHFR C677T/A1298C Patients With Major Depressive Disorder : an Analysis of Findings

A randomized double-blind placebo controlled study of reduced B vitamins in patients with major depression who were positive for one or both of the common MTHFR polymorphisms was conducted between 8/1/2014 and 4/3/2015. Homocysteine levels and MADRS scores were used as primary measures. The study was designed to test safety and efficacy of reduced B vitamins in MDD associated with MTHFR. This study examines the data from the trial to see effects, effect sizes, and further, if demographic factors and other patient characteristics correlated with findings.

Start Date01 Aug 2013

Sponsor / Collaborator

High Point Regional Health System, Inc.

100 Clinical Results associated with High Point Regional Health System, Inc.

0 Patents (Medical) associated with High Point Regional Health System, Inc.

Literatures (Medical) associated with High Point Regional Health System, Inc.

01 Apr 2015·The Journal of Community and Supportive Oncology

Feasibility of implementing a community-based randomized trial of yoga for women undergoing chemotherapy for breast cancer

Article

Author: Griffin, Leah P ; Sohl, Stephanie J ; Giguere, Jeffrey K ; Wiliford, Susan K ; Shaw, Edward ; Jesse, Michelle T ; Lucas, Shantae L ; Avis, Nancy E ; Lawrence, Julia A ; Danhauer, Suzanne C ; Addington, Elizabeth L ; Messino, Michael J

BACKGROUNDTreatment-related symptoms and decreased health-related quality of life (HRQoL) frequently occur during chemotherapy for breast cancer. Although research findings suggest that yoga can reduce symptoms and Improve HRQoL after treatment, potential benefits of yoga during chemotherapy have received minimal attention.OBJECTIVETo estimate accrual, adherence, study retention, and preliminary efficacy of a yoga intervention compared with an active control group for breast cancer patients during chemotherapy.METHODSWomen with stage I-III breast cancer were recruited from 3 community cancer clinics and randomized to 10 weeks of gentle yoga or wellness education. Depressive symptoms, fatigue, sleep, and HRQoL were assessed at baseline, mid-intervention (Week 5), and after intervention (Week 10).RESULTS40 women aged 29-83 years (median, 48 years; 88% white) were randomized to yoga (n = 22) or wellness education (n = 18). The groups did not differ significantly on baseline characteristics, adherence, or study retention. Participant feedback was positive and comparable between groups. Meaningful within-group differences were identified For sleep adequacy and quantity in yoga participants and for somnolence in wellness-education participants.LIMITATIONSSmall sample size and lack of a usual-care control group.CONCLUSIONSThis study established Feasibility of a community-based randomized trial of yoga and an active comparison group for women undergoing chemotherapy for breast cancer. Preliminary efficacy estimates suggest that yoga improves sleep adequacy Symptom severity and interference remained stable during chemotherapy for the yoga group and snowed a trend toward increasing in the control group. The study highlighted obstacles to multisite yoga research during cancer treatment.FUNDING/SPONSORSHIPNational Cancer Institute (3U10 CA081851, PI; Shaw; R25 CA122061, PI: Avis); Translational Science Institute, Wake Forest School of Medicine.

01 Aug 2011·Nursing Management

Taking the pressure off in the ICU

Article

Author: Gammons, Karen ; Dunzweiler, Susan ; Hinson, Laura

01 Jan 2009·CNS SpectrumsQ3 · MEDICINE

The Role of L-Methylfolate in Depressive Disorders

Q3 · MEDICINE

Review

Author: Farah, Andrew

Major depressive disorder (MDD) is a debilitating illness affecting 7% to 12% of men and 20% to 25% of women. It is usually a recurrent illness, with up to 30% of patients experiencing a depressive episode lasting over 2 years. Depression may also increase the morbidity and mortality of numerous medical conditions, such as cardiac disease, myocardial infarction, chronic pain, diabetes, cerebrovascular events, and respiratory illnesses. The goal of antidepressant therapy is to achieve full remission and functional recovery, and continuing treatment beyond the acute phase is usually necessary to maintain remission. In contrast with full remission, individuals who experience residual symptoms, however mild, have a higher chance of experiencing one or more additional episodes.

100 Deals associated with High Point Regional Health System, Inc.

100 Translational Medicine associated with High Point Regional Health System, Inc.

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 20 Nov 2024

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

High Point Regional Health System, Inc.

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 20 Nov 2024

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing