Ascend Biopharmaceuticals Ltd.

The primary objectives are to:
Evaluate the safety and tolerability of intralesional ASN-002 when administered in combination with oral vismodegib in patients with Basal Cell Carcinomas (BCC)s;
Evaluate the efficacy of intralesional ASN-002 in target tumours when administered in combination with oral vismodegib in patients with BCCs.
The secondary objective is to:
1) Evaluate the efficacy of intralesional ASN-002 in non-target tumours when administered in combination with oral vismodegib in patients with BCCs.
The exploratory objective is to:
1) Evaluate immunological biomarkers during the course of treatment.

The primary objective is to confirm the safety of treating multiple BCCs once weekly x 3 weeks in individuals with Basal Cell Nevus Syndrome (BCNS).
The secondary objectives of the study are to obtain preliminary data on the effectiveness of ASN-002 in the treatment of BCCs in individuals with Basal Cell Nevus Syndrome (BCNS) by
evaluating the histological clearance of BCCs in patients with BCNS, and
assessing the clinical changes of BCCs after treatment with ASN-002, and
assessing the systemic effect of ASN-002 by determining response in non-injected lesions
assess the safety and clinical changes after a second cycle of ASN-002 injections