Prognostic Effect of Herpes Simplex Virus Type 1 Infection/Reactivation in the Lower Respiratory Tract of Critical Care Patients With Severe Pneumonia（the HSV-SP Study）: a Study Protocol for a Multicenter, Prospective Cohort Study

Severe pneumonia(SP) is a one of the main causes of death for critically ill patients.Samples of bronchoalveolar lavage fluid (BALF) from SP patients often report positive for herpes simplex virus type 1 (HSV-1) DNA. However, to date, it is unclear the impact and significance of this positive result on SP patients. This study will evaluate the prognostic impact of lower respiratory tract HSV-1 infection/reactivation on ICU severe pneumonia patients.At the same time, by analyzing the risk factors that affect prognosis, we will identify populations with the potential for intervention benefits and provide a basis for further intervention treatment.

Start Date01 Jun 2025

Sponsor / Collaborator

Second Affiliated Hospital of Guangzhou Medical University

[+3]

ChiCTR2500096276

/ SuspendedNot ApplicableIIT

Comparison of postoperative effects of PS and CR knee arthroplasty

Start Date10 Feb 2025

Sponsor / Collaborator

Guangzhou Red Cross Hospital

100 Clinical Results associated with Guangzhou Red Cross Hospital

0 Patents (Medical) associated with Guangzhou Red Cross Hospital

1,099

Literatures (Medical) associated with Guangzhou Red Cross Hospital

31 Dec 2025·Organogenesis

Correlation of MicroRNA-31 with Endometrial Receptivity in Patients with Repeated Implantation Failure of In Vitro Fertilization and Embryo Transfer

Article

Author: Tan, Yan ; Chen, Minhong ; Chen, Xixi ; Du, Bijun

OBJECTIVEThis trial probed the correlation between miR-31 expression and endometrial receptivity (ER) in patients with repeated implantation failure (RIF) of in vitro fertilization and embryo transfer (IVF-ET).METHODSA retrospective study of 80 infertility patients who underwent IVF-ET assisted conception treatment were divided into RIF group and normal pregnancy group (control group) according to the pregnancy outcome after embryo transfer. General information of both groups was collected. Endometrial tissues were collected in the middle luteal phase of the menstrual cycle before IVF-ET. miR-31 levels in endometrial tissues were measured, and endometrial tolerance indicator pulsatility index (PI), resistance index (RI), and endometrial thickness (Em) were detected. The correlation between endometrial miR-31 levels and ER indices was evaluated by Pearson method. ROC curves were utilized to analyze the efficacy of miR-31 in predicting RIF occurrence. The influencing factors of RIF were analyzed by binary Logistic regression.RESULTSRIF patients had increased miR-31 expression level and endometrial tolerance indicator PI, and RI while decreased Em (p < 0.05). miR-31 in RIF patients was positively correlated with PI and RI, and negatively correlated with Em (p < 0.05). The area under the curve for miR-31 to predict the occurrence of RIF was 0.899, with a sensitivity of 0.750 and a specificity of 0.950. PI, RI, and miR-31 were risk factors for developing RIF in IVF-ET women, and Em was a protective factor (p < 0.05).CONCLUSIONmiR-31 in RIF patients is positively correlated with PI and RI, and negatively correlated with Em.

01 Jun 2025·Materials Today Bio

Novel pH-responsive lipid nanoparticles deliver UA-mediated mitophagy and ferroptosis for osteoarthritis treatment

Article

Author: Yi, Guoliang ; Song, Xizheng ; Liu, Jianghua ; Zhang, Haowei ; Li, Min ; Li, Jinxin ; Zhou, Jiayi ; Li, Siming ; Chen, Zhiwei

Synovial inflammation plays a crucial role in osteoarthritis (OA) development, leading to chronic inflammation and cartilage destruction. Although targeting synovitis can alleviate OA, clinical outcomes have been disappointing due to poor drug targeting and joint cavity heterogeneity. This study presents pH-responsive lipid nanoparticles (LNPs@UA), loaded with Urolithin A (UA), as a potential OA treatment. LNPs@UA showed uniform particle size, low zeta potential, and effective mitochondria-targeting and pH-responsive capabilities. In vitro, LNPs@UA reduced reactive oxygen species (ROS), pro-inflammatory factors (IL-1β, IL-6, TNF-α), and promoted M2 macrophage polarization. It improved mitochondrial structure, enhanced autophagy, and inhibited ferroptosis. In vivo, LNPs@UA alleviated OA progression in an ACLT-induced OA mouse model. Transcriptomic analysis revealed inhibition of NF-κB signaling and activation of repair pathways. These results suggest LNPs@UA could offer a promising therapeutic approach for OA.

25 Mar 2025·Current Medical Imaging Formerly Current Medical Imaging Reviews

Recurrence of Pleomorphic Adenoma in the Submandibular Gland: A Case Report and Literature Review

Article

Author: Xu, Fan ; Li, Zhiqiong ; Xiong, Yuchao ; Yuan, Guiying ; Huang, Junbin ; Zhang, Ye ; Zeng, Xuwen

Introduction: Recurrent pleomorphic adenoma (PA) in the submandibular gland is a rare tumor that may be misdiagnosed as an inflammatory lesion. The imaging manifestations of the submandibular gland recurrent PA are unclear, with only three case reports reporting CT and MRI imaging, respectively. Our report is the first case report that comprehensively describes the imaging manifestations of recurrent PA in the submandibular gland. Case Presentation: A 28-year-old woman had a right submandibular gland pleomorphic adenoma that recurred 5 years after resection and gradually grew larger. She had no special discomfort and was diagnosed with a recurrence of pleomorphic adenoma. The patient underwent CT and MRI examinations and tumor resection, and postoperative pathology showed tumor recurrence. Conclusion: This case report provides substantial and comprehensive CT and MRI data, which is conducive to the diagnosis of the recurrence of submandibular gland pleomorphic adenoma and the avoidance of misdiagnosis to the greatest extent possible.

100 Deals associated with Guangzhou Red Cross Hospital

100 Translational Medicine associated with Guangzhou Red Cross Hospital

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