Melasma is a common hyperpigmentation disorder, characterized by light-to-dark brown patches, usually distributed on sun-exposed areas of the body. The objective of this study was to evaluate the efficacy and tolerability of an oral nutritional supplement containing Pinus pinaster and Grape seed extract, vitamins and minerals, used concomitantly with a high SPF sunscreen in 30 women with mild-to-moderate facial melasma. Efficacy was assessed by measurement of the melasma area and severity index (MASI), instrumental anal. of the lesions (Mexameter, VISIA) and patient's and physician's global assessment (PGA). The MASI score decreased significantly compared with baseline at days 28, 56, and 84. Mexameter anal. showed a significant decrease of ΔM (difference in the melanin index between melasma and adjacent area). VISIA results also showed a reduction in the number and areas of UV pigmented spots and in the areas of melasma overtime. Both the patient's and physician's global assessment showed that the product led to an improvement of the lesions in terms of depigmentation and had pos. cosmetic features without adverse events. The oral supplement subject of this study in combination with high SPF sunscreen was effective and well-tolerated for treatment of mild to moderate facial melasma.