University of Chieti-Pescara

TUESDAY, Dec. 17, 2024 -- For patients with hypertension and ischemic stroke, the risk for poststroke epilepsy (PSE) varies according to antihypertensive treatment, according to a study presented at the annual meeting of the American Epilepsy Society, held from Dec. 6 to 10 in Los Angeles. Giacomo Evangelista, M.D., Ph.D., from the "G. d'Annunzio" University of Chieti-Pescara in Italy, and colleagues examined the effectiveness of antihypertensive treatment in preventing PSE in a retrospective, observational study. Patients with hypertension and diagnosis of ischemic stroke were retrospectively selected; all participants were followed up for PSE at a mean of 66 months. The researchers found that 38 of the 528 patients (7.2 percent) developed PSE. The risk for PSE development was higher in association with anterior cerebral artery involvement and cortico-sottocortical lesions. The risk for PSE was lower in patients treated with angiotensin receptor blockers, while incidence was higher for those receiving calcium channel blockers and beta-blockers. No differences were seen for angiotensin-converting enzyme inhibitor use. "These findings highlight the importance of personalized medicine, particularly in managing blood pressure in stroke patients," co-lead author Fedele Dono, M.D., also from G. d'Annunzio University of Chieti-Pescara, said in a statement. "Further research in more patients is necessary to confirm these findings and explore the underlying mechanisms in more detail." Press Release More Information Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

This Study Will Help Assess the Time Necessary for Tetranite® to Regenerate Bone in the Oral Environment LOWELL, Mass.--(BUSINESS WIRE)-- RevBio, Inc., announced that it has received approval from the Italian Ministry of Health and the Ethics Committee of the University “G.D'Annunzio” of Chieti-Pescara to start a 15-patient pilot clinical trial. The primary objective of this study will be to assess the time it takes for Tetranite®, the company’s adhesive biomaterial, to regenerate bone in the mandibular and maxillary dental arches. This press release features multimedia. View the full release here: Prior studies have demonstrated that TETRANITE® is replaced with bone via substitution as it dissolves, stimulating osteoblast cells to produce osteoid (bone precursor) which is then mineralized during the process of bone maturation. (Graphic: Business Wire) This study will be conducted at the Center for Advanced Studies and Technology (“CAST”) of the University “G.d’Annunzio” Chieti-Pescara under the leadership of Professor Sergio Caputi, MD, DDS, who serves as the Chancellor/Provost of the University. The research team also includes Professor Maurizio Piattelli, MD, DDS, Tonino Traini, DDS, PhD, Bruna Sinjari, DDS, PhD, Gianmaria D’Addazio, DDS, PhD, and Manlio Santilli, DDS, PhD Student. This team is part of the Department of Innovative Technologies in Medicine and Dentistry where novel and cutting-edge research in dentistry is conducted. “We are very pleased to see this study come together after much planning during the COVID-19 pandemic,” said Dr. Sinjari. “We have assembled a great research team which will be able to assess the unique osteoconductive properties of this biomaterial.” Currently there are no products approved in Europe or the United States that are adhesive to bone and capable of bonding dental implants into place while gradually resorbing and being replaced by new, native bone. These properties have been demonstrated in prior studies, but the focus of this study will be to assess the timescale when the material is resorbed by the human body, which will help determine the length of future clinical trials necessary for obtaining commercial approval. Dr. Paul Fugazzotto, DDS, an advisor to RevBio, and a noted lecturer, dental educator, and periodontist, introduced the company to the research team at the University of Chieti. “The design of this study will answer some important questions that will help evidence the key advantages of this biomaterial,” said Dr. Fugazzotto. “I believe this technology will be transformative in the way we place dental implants.” About RevBio, Inc. RevBio, Inc., is a clinical stage medical device company engaged in the development and commercialization of a patented, synthetic, injectable, self-setting, and osteoconductive bone adhesive biomaterial called Tetranite®. The company is initially developing this technology for use in the dental, cranial, and broader orthopaedic markets as well as applications in the animal health market. RevBio's Tetranite technology is not yet approved for commercial use. View source version on businesswire.com: Contacts Michael Tiedemann mtiedemann@revbio.com Source: RevBio, Inc. Smart Multimedia Gallery Photo Prior studies have demonstrated that TETRANITE® is replaced with bone via substitution as it dissolves, stimulating osteoblast cells to produce osteoid (bone precursor) which is then mineralized during the process of bone maturation. (Graphic: Business Wire) Logo View this news release and multimedia online at:

WASHINGTON--(BUSINESS WIRE)-- Altoida, Inc., a precision neurology company pioneering non-invasive brain health measurement and neurological disease diagnostics with AI and augmented reality (AR), today announced the appointment of Dr. Antonella Santuccione Chadha as Chief Medical Officer. In this new role, Dr. Chadha will lead all clinical and medical affairs as the company continues to develop, validate, and commercialize its AI-driven digital biomarker platform. She will report directly to the Chief Executive Officer of Altoida, Travis Bond, and will serve on the Leadership team. Dr. Chadha is a medical doctor and internationally recognized expert in clinical pathology, neuroscience, neurological disease, and psychiatric disorders. She brings decades of global experience in clinical research and development, commercialization, patient engagement, and regulatory strategy. Prior to joining Altoida, Dr. Chadha served as the Head of Stakeholder Engagement for Alzheimer’s Disease at Biogen. She is the co-founder and pro-bono CEO of the Women’s Brain Project, a non-profit organization dedicated to addressing the influence of sex and gender on mental health, brain health, and neurological diseases. She is a decorated researcher, having studied novel immunotherapies for Alzheimer’s disease in the laboratory of Roger Nitsch and Christoph Hock at the University of Zurich where aducanumab, the first amyloid treatment for Alzheimer’s, was discovered. Her additional experience spans the Swiss Agency for Therapeutic Products, Roche Diagnostics and Roche Pharmaceuticals, the EU Commission Directorate for Health and Food Safety, the OECD, the CEOi, and several other Alzheimer’s Disease organizations. “Dr. Chadha is a true maverick in the field of neuroscience and a pioneer in utilizing precision technologies to improve the way we measure brain health and diagnose neurological diseases. She has led high-performing teams in the private, public, and non-profit sectors, and has a proven track record of success in R&D, clinical, and regulatory affairs,” said Travis Bond, Chief Executive Officer at Altoida. “She will be an invaluable asset to Altoida and our leadership team as we expand our platform and advance our deep pipeline of novel digital biomarkers for Alzheimer’s, and other neurological and neuropsychiatric disorders.” “I am thrilled to join Altoida at such a dynamic time. The company is developing its platform to improve patient outcomes across a breadth of neurological diseases, including Alzheimer’s. The company’s proprietary AI and augmented reality technology will be transformative in the early and accurate detection of Alzheimer’s and across the entire neurological disease drug development lifecycle. I look forward to working with Travis and the Altoida team to reduce the time and cost to diagnose complex and devastating conditions like Alzheimer’s, by bringing innovative, precise digital measurements and diagnostics to patients in need,” said Dr. Antonella Santuccione Chadha, Chief Medical Officer at Altoida. Dr. Chadha completed her Doctor of Medicine (M.D.) with a focus on Neuroscience at the University of Chieti, Italy. She continued her postgraduate education across several European universities such as the Center for Molecular Neurobiology in Hamburg and the University of Zurich. She is the author of several peer-reviewed papers about Alzheimer’s disease, policy applied to neuroscience, and the influence of sex and gender on mental and brain diseases. She continues to serve as a member of the scientific committee of the European College of Neuropsychopharmacology 2022 and pro bono Vice President of Euresearch. About Altoida, Inc. Altoida is building the world’s leading platform to accelerate and improve drug development, research, and care for patients with neurological diseases. The company’s innovative AI-driven approach leverages immersive augmented reality (AR) to evaluate the brain in a comprehensive, real-world mode of functioning using data captured with a standard smartphone or tablet. Altoida’s validated and evidence-based digital biomarker platform received FDA Breakthrough Device Designation and is supported by more than 20 years of scientific research and publications in journals like Nature Digital Medicine. Altoida is based in Washington, DC. For more information, visit . Follow us on LinkedIn and Twitter at @altoida.