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Overview

An open label, balanced, randomized, two-treatment, two-period, two-sequence, single oral dose, crossover, bioequivalence study of Ibuprofen sodium dihydrate 512 mg tablets of Lyrus Life Sciences Pvt. Ltd., In comparison with Nurofen Pain Relief Max Strength 512 mg Tablets (Ibuprofen sodium dihydrate 512 mg) of Reckitt Benckiser Healthcare Ltd. , in healthy, adult, human subjects under Fed conditions.

Start Date22 Jul 2022

Sponsor / Collaborator

Lyrus Life Sciences Pvt Ltd.Startup

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Literatures (Medical) associated with Lyrus Life Sciences Pvt Ltd.

Himalayan Journal of Health Sciences

A Review: Novel Granulation Technology

Author: Saravanan, S. ; Bisht, Meena ; S, Saravanan

All the pharmaceutical Active pharmaceutical Ingredients (API) and Pharmaceutical excipients will have different particle size. While formulating a dosage form, particles from raw materials will tend to separate from other due to their rheological properties. There could be a condition where fine particles separate from the larger particles causing demixing or uneven distribution of active with its excipients leading to tablet content uniformity issue. To overcome this problem, particle enlargement or particle cohesiveness with or without additional aid is necessary, which could be achieved by granulation. Hence granulation technology is important in the formulation of pharmaceutical oral solid dosage form. Granulation is the process of adhering fine particles agglomerate into a large particle using two most common methods i.e. wet granulation and dry granulation/compaction. Day by day technological innovation is happening in all fields and pharmaceutical granulation process is also not an exemption. The objective of present review is to focus the novel granulation technology and how it is differing from the conventional granulation technology.

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