Delving into the Latest Updates on First Affiliated Hospital of Harbin Medical University with Synapse

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Cardiovascular Diseases

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Recombinant polypeptide

Cell therapy

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Top 5 Drug Type	Count

Cell therapy	1
Recombinant polypeptide	1

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SPX(spexin hormone)	1
TGF-β1(Transforming growth factor beta 1)	1

The goal of this multicenter, randomized trial is to compare standby cannulated ECMO versus prophylactic ECMO in patients undergoing high-risk percutaneous coronary intervention (PCI). The main question it aims to answer is :
• If standby cannulated ECMO as compared with prophylactic ECMO will improve the outcomes in patients undergoing high-risk PCI

Start Date01 Dec 2024

Sponsor / Collaborator

Beijing Anzhen Hospital

[+9]

NCT06565845

/ RecruitingNot ApplicableIIT

Analysis of the Clinical Characteristics and Three Treatment Methods of Granulomatous Lobular Mastitis

Granulomatous lobular mastitis (GLM) is a rare benign breast disease that is difficult to distinguish from breast cancer based on clinical and imaging findings, and there is currently no standard treatment. This study aims to analyze the clinical characteristics and demographic data of GLM patients and to compare the overall effectiveness of three treatment methods: surgery alone, triple anti-tuberculosis drug therapy alone, and combined surgery with triple anti-tuberculosis drug therapy, with the goal of providing new insights for clinical treatment.

Start Date19 Aug 2024

Sponsor / Collaborator

First Affiliated Hospital of Harbin Medical University

100 Clinical Results associated with First Affiliated Hospital of Harbin Medical University

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0 Patents (Medical) associated with First Affiliated Hospital of Harbin Medical University

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100

Literatures (Medical) associated with First Affiliated Hospital of Harbin Medical University

01 Dec 2025·Asia-Pacific Journal of Oncology Nursing

Barriers to implementation of preoperative urostomy site marking in nurse-physician cooperation: A qualitative study based on the Theoretical Domains Framework

Article

Author: Liu, Chunxia ; Zhang, Xiaotian ; Shi, Rui ; Pang, Dong ; Ma, Xueqian ; Ye, Jianfei ; Liu, Jing ; Zhang, Lei ; Wang, Jia ; Zhang, Haihong ; Jia, Xiaojun ; Chen, Jianying ; Cui, Liyan ; Li, Xiaolong ; Zhang, Haifang

ObjectiveThis study aimed to understand the barriers to nurse-physician collaboration in implementing preoperative stoma site marking using qualitative research methods following Theoretical Domain Framework.MethodsA qualitative descriptive study using semi-structured interviews was conducted from March to June 2023 in the urology departments of nine tertiary hospitals in China. Twelve urologists and eight enterostomal therapists (ETs) were recruited using purposive sampling. Audio recordings were transcribed verbatim and data were analyzed using content analysis.ResultsFive themes were identified in the study: shortage of manpower and stoma care products, lack of standard and regulations, lack of motivation and intention, inconsistency of expectation on consequences, and difficulties in cooperation.ConclusionThis study indicated that the barriers to implementation of preoperative urostomy localization among urologists and ETs. Institutions, resources, clear career plans, and performance feedback can increase motivation and intention. In addition, the lack of cooperation between urologists and ETs is a key factor for poor urostomy localization implementation, which calls for effective and equal communication between doctors and nurses.

01 Jun 2025·Biomedical Signal Processing and Control

MultiBCD: A multimodal model that simulates the human diagnostic process for automated breast cancer detection

Author: Tao, Weiyang ; Du, Juntong ; Zhang, Zihan

To enhance the accuracy of BC detection, our study introduces MultiBCD, a multimodal model that emulates the human diagnostic process for BC detection.Integrating an image classifier with GPT-4, it evaluates mammog. images alongside patient complaints.The model′s dual-head autoencoder efficiently processes image data, eliminating the need for manual lesion delineation, while GPT-4 extracts critical information from patient narratives.MultiBCD demonstrates superior diagnostic accuracy and efficiency, achieving an F1 score of 80.15% and a recall rate of 90.68%, which marks an improvement over traditional methods.Furthermore, its design, emphasizing interpretability, aligns with the intuitive experience of medical consultations.The encouraging results of MultiBCD in BC detection indicate its potential for application in similar diagnostic contexts.The MultiBCD model is characterized by its compact structure, flexible and efficient coupling, and the open-sourcing of its code(https://github.com/zhangzihan-is-good/AI-breast-cancer), thereby enhancing the model′s practical utility.

01 May 2025·Redox Biology

Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cells

Article

Author: Yue, Ziyong ; Liu, Chang ; Zhang, Yan ; Bu, Yue ; Li, Chenglong ; Chen, Guangmin ; Han, Lei ; Ma, Zhaoxue ; Cao, Hang ; Wang, Cheng ; Li, Zhixi ; Yu, Yongjing

Macrophages play a critical role in the development of sepsis-induced acute lung injury (si-ALI), with extracellular vesicles (EVs) acting as crucial mediators. However, the effects and mechanisms of macrophage-derived EVs on si-ALI remain unclear. This study demonstrated that macrophage-derived EVs induce endothelial ferroptosis and barrier disruption during sepsis. Through proteomic sequencing and reanalysis of transcriptomic and single-cell sequencing data, guanylate-binding protein 2 (GBP2) was identified as a key EV molecule. Elevated GBP2 expression was observed in EVs and monocytes from the peripheral blood of sepsis patients, in LPS-stimulated THP-1 and RAW264.7 cells and their secreted EVs, and in macrophages within the lungs of CLP mice. Additionally, GBP2 expression in EVs showed a positive correlation with vascular barrier injury biomarkers, including ANGPT2, Syndecan-1, and sTM. Modulating GBP2 levels in macrophage-derived EVs affected EV-induced ferroptosis in endothelial cells. The mechanism by which GBP2 binds directly to OTUD5 and promotes GPX4 ubiquitination was elucidated using RNA interference, adeno-associated virus transfection, and endothelial-specific Gpx4 knockout mice. A high-throughput screening of small-molecule compounds targeting GBP2 was conducted. Molecular docking, molecular dynamics simulations, and cellular thermal shift assays further confirmed that Plantainoside D (PD) has a potent binding affinity for GBP2. PD treatment inhibited the interaction between GBP2 and OTUD5, leading to a reduction in GPX4 ubiquitination. Further research revealed that PD treatment enhanced the pulmonary protective effects of GBP2 inhibition. In conclusion, this study explored the role of EV-mediated signaling between macrophages and pulmonary vascular endothelial cells in si-ALI, highlighting the GBP2-OTUD5-GPX4 axis as a driver of endothelial ferroptosis and lung injury. Targeting this signaling axis presents a potential therapeutic strategy for si-ALI.

100 Deals associated with First Affiliated Hospital of Harbin Medical University

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100 Translational Medicine associated with First Affiliated Hospital of Harbin Medical University

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Pipeline

Pipeline Snapshot as of 18 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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