A Randomized study to Compare Analgesic Efficacy of Ropivacaine with Dexmedetomidine Versus Ropivacaine with Magnesium fulfate in Surgical Site Infiltration in Patients Undergoing Lumbar Spine Fixation Surgery under General Anaesthesia - Nil

Start Date27 Apr 2025

Sponsor / Collaborator

SMS Medical College & Hospital

CTRI/2024/11/076895

/ Not yet recruitingNot ApplicableIIT

A randomised study to compare intravenous granisetron versus ondensetron on hemodynamics sensory and motor block after spinal anaesthesia with hyperbaric bupivacaine in patients undergoing lower segment caesarean section - NIL

Start Date25 Nov 2024

Sponsor / Collaborator

SMS Medical College & Hospital

CTRI/2024/10/074799

/ Not yet recruitingNot ApplicableIIT

An interventional study to compare refractory outcomes in combined silicone oil removal and phacoemulsification in by using IOL Master and intra operative biometry - nil

Start Date16 Oct 2024

Sponsor / Collaborator

SMS Medical College & Hospital

100 Clinical Results associated with SMS Medical College & Hospital

0 Patents (Medical) associated with SMS Medical College & Hospital

525

Literatures (Medical) associated with SMS Medical College & Hospital

01 Mar 2025·World Neurosurgery

Computed Tomography Cerebral Perfusion to Predict Functional Outcome in Pediatric Head Injury: A Comparative Study of Voxel-Based and Whole-Brain Perfusion

Article

Author: Bhaskar, Mukesh ; Babal, Rohit ; Agrawal, Manish ; Kumar, Jagadeesh ; Jain, Nikhil Kumar

OBJECTIVEThis study evaluates the extent of perfusion abnormalities in pediatric patients with traumatic head injury by using computed tomography (CT) perfusion (CTP) and compares the efficacy of voxel-based and whole-brain perfusion data clinically with the functional outcome scales Glasgow Outcome Scale Extended-Pediatric Revision and modified Rankin Scale (mRS).METHODSIn this prospective study, 100 eligible patients aged 0-15 years were enrolled. Patients were categorized into having mild, moderate, and severe traumatic brain injury using the Glasgow Coma Scale. CTP scans were performed at admission and at the time of discharge. Both voxel-based and whole-brain perfusion data were acquired at 5 regions of interest: orbitofrontal cortex, internal capsule, thalamus, caudate nucleus, and sensorimotor cortex for cerebral blood perfusion. The extent of perfusion abnormalities was noted in CTP scans. The Glasgow Outcome Scale Extended-Pediatric Revision and modified Rankin Scale were used to clinically evaluate functional outcomes.RESULTSSignificant differences in CTP findings between voxel-based and whole-brain approaches were noted. Voxel-based scans showed superior predictive value in severe cases, whereas whole-brain scans were promising in moderate cases. Glasgow Coma Scale scores and specific CT parameters (cerebral blood flow and mean transit time.) were also significant predictors of outcomes.CONCLUSIONSThe comparative analysis highlights the complementary roles of voxel-based and whole-brain perfusion CT in predicting functional outcomes in pediatric patients with head injury. Clinicians should consider both approaches when evaluating cerebral perfusion status and making treatment decisions. Further research is warranted to validate these findings and refine imaging protocols to optimize predictive accuracy in this vulnerable population.

01 Mar 2025·Global Medical Genetics

Limb-Girdle Muscular Dystrophies (LGMD): Clinical features, diagnosis and genetic variability through next generation sequencing

Article

Author: Kaur, Ashmeet ; Mathur, Priyanshu ; Agarwal, Kamlesh ; Vijay, Urvashi ; Gupta, Ashok ; Agrawal, Lokesh

BackgroundLimb-Girdle Muscular Dystrophy (LGMD) is a rare heterogeneous group of neuromuscular disorders distinguished by progressive weakness of limb-girdle muscles. Diagnosis of LGMD is a challenging task and requires multiple obligatory assays.ObjectiveTo study the epidemiology, clinical features, the genetic variability in patients diagnosed with LGMD through Next Generation Sequencing.Material and MethodA retrospective study of 27 patients suspected of LGMD was done to study the phenotypic presentation and the genotypic alteration of the patients, presenting to a tertiary care center in Rajasthan were studied.ResultsOut of the twenty-seven patients suspected of LGMD, nineteen patients took genetic tests, while eight patients underwent biopsy. Among the nineteen patients, seventeen patients were identified with pathogenic mutations. Autosomal Recessive (LGMD-R) was the most common subgroup in this cohort. In the LGMD R1 subgroup, the most common mutation was c.2051-1 G>T and the exon hotspot was 18-22. The deleterious mutations in the LGMD R2 subgroup were distributed along the entire coding sequence, without any hotspot. However, C2E, C2F, and DysF domains contain variants at higher frequencies. The types of mutations were mostly point mutations (34 % of missense mutations and 66 % of nonsense mutations). We identified one novel mutation which was considered as a stop codon. Patients(n = 8) who underwent muscle biopsy for immunohistochemistry, had absent/reduced sarcoglycan uptake (n = 4) or absent dysferlin (n = 2) on the sarcolemma, while the remaining two biopsies were inconclusive (due to multiple protein deficiencies).

01 Jan 2025·INDIAN JOURNAL OF APPLIED RESEARCH

A PROSPECTIVE OBSERVATIONAL STUDY ON EFFECT ON SEMEN PARAMETERS AFTER COUNSELLING IN THE DEPARTMENT OF OBSTETRICS & GYNAECOLOGY, SMS MEDICAL COLLEGE & HOSPITAL, JAIPUR

Author: Meena, Kusumlata ; Sharma, Swati

This observational study evaluated the impact of lifestyle-related factors on male fertility and the effectiveness of counseling in improving semen parameters among 200 males attending a specialty clinic. Modern lifestyle habits, including obesity, sedentary behavior, excessive mobile phone usage, smoking, alcohol consumption, and junk food intake, have been linked to declining sperm quality, as evidenced by reduced sperm concentration, motility, vitality, and morphology. Participants were assessed for these habits and counseled to adopt healthier lifestyle choices. The findings revealed that these factors significantly contributed to male infertility by affecting semen quality and reproductive health. Counseling resulted in measurable improvements in all semen parameters, including sperm concentration, motility, and morphology, while also enhancing endocrine control of reproductive functions. Notably, 31% of the participants' spouses conceived after lifestyle modification, underscoring the potential of targeted counseling in addressing male infertility. This study highlights the critical role of lifestyle interventions in improving male reproductive health and supports their inclusion in infertility treatment protocols.

100 Deals associated with SMS Medical College & Hospital

100 Translational Medicine associated with SMS Medical College & Hospital

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