A comparative study of effect of intrathecal hyperbaric Ropivacaine 0.75% vs hyperbaric Bupivacaine 0.5% for postoperative analgesia in Infraumblical surgeries - nil

Start Date07 Mar 2025

Sponsor / Collaborator

Jawaharlal Nehru Medical College & Hospital

CTRI/2024/10/075691

/ Not yet recruitingNot ApplicableIIT

To explore the applicability of Boger Boenninghausens Characteristics Repertory in management of Bronchial asthma. - NIL

Start Date06 Nov 2024

Sponsor / Collaborator

Jawaharlal Nehru Medical College & Hospital

CTRI/2024/09/074101

/ Not yet recruitingPhase 2IIT

Efficacy of Individual Homeopathic Medicine in cases of Fibromyalgia; A Clinical, Randomized Placebo-controlled Trial Using Revised Fibromyalgia Impact Questionnaire. - nil

Start Date01 Nov 2024

Sponsor / Collaborator

Jawaharlal Nehru Medical College & Hospital

100 Clinical Results associated with Jawaharlal Nehru Medical College & Hospital

0 Patents (Medical) associated with Jawaharlal Nehru Medical College & Hospital

Literatures (Medical) associated with Jawaharlal Nehru Medical College & Hospital

01 Jan 2025·BMJ Case Reports

Liquorice-induced pseudohyperaldosteronism: a rare cause for severe hypertension

Article

Author: Nair, Sasikumar ; Karthik, Vijayakumar ; Alam, Ahmad ; Asok, Arsha Chandrasobha

This case report describes an adult man in his 50s with a history of type 2 diabetes and previously well-controlled hypertension, who presented with uncontrolled hypertension, muscle weakness and fatigue. Biochemical testing revealed hypokalaemia. There was no evidence of renal/renovascular disease. Evaluation for primary hyperaldosteronism revealed suppressed renin concentration with low aldosterone levels. Detailed history taking revealed the daily consumption of three to four cups of liquorice root tea for 3 months. Glycyrrhetinic acid, a metabolite of glycyrrhizic acid found in liquorice, inhibits the 11 beta-hydroxysteroid dehydrogenase-2 (11β-HSD2 enzyme present at the renal tubule, leading to cortisol-mediated mineralocorticoid receptor activation. The diagnosis of liquorice-induced pseudohyperaldosteronism was made, and the discontinuation of liquorice with short-term use of mineralocorticoid receptor blockers led to normalisation of blood pressure and serum potassium. This case highlights the importance of considering the possibility of excess use of liquorice in the differential diagnosis of unexplained hypertension, especially in the context of low-renin hypertension.

01 Jan 2025·BMJ Case Reports

Precocious puberty: the unlikely herald of Familial adenomatous polyposis in a young girl

Article

Author: Alam, Ahmad ; Jabbar, Puthiyaveetil Khadar ; Karthik, Vijayakumar ; Nair, Abilash

We describe the case of a girl in her middle childhood who presented with signs of heterosexual precocious puberty in the form of axillary and pubic hair growth, acne and clitoromegaly. Investigations showed elevated androgens and autonomous cortisol excess, suggesting an adrenal source. CT imaging confirmed a left adrenal mass and multiple colonic polyps. The family history of colonic polyps in her father, along with the presence of congenital hypertrophy of the retinal pigment epithelium and colonic polyps on colonoscopy, led to a diagnosis of familial adenomatous polyposis (FAP), subsequently confirmed by genetic testing. The patient underwent a successful adrenalectomy, with histopathology confirming an adrenocortical adenoma. Postsurgery, her hormonal levels normalised and symptoms improved. This case presents a unique combination of heterosexual precocious puberty caused by a cortisol and androgen co-secreting adrenal tumour in a girl with FAP, highlighting the complex interplay between endocrine disorders and genetic syndromes.

04 Dec 2024·Cureus

Audiological Outcome of Tympanoplasty With Mastoidectomy in Middle-Aged and Younger Patients With Chronic Otitis Media

Article

Author: Beig, Sabeeh ; Saini, Saurabh ; Khan, Saquib Reyaz ; Singhal, Vanshika

OBJECTIVEChronic otitis media (COM) is characterized by chronic, intermittent, or persistent discharge through a perforated tympanic membrane. In this study, we aimed to evaluate the postoperative audiological outcomes in middle-aged patients compared to younger patients who underwent tympanoplasty with mastoidectomy via post-auricular approach for the treatment of COM.METHODSThis prospective interventional study included patients admitted in wards from August 2017 to January 2019 at the Department of Otorhinolaryngology, Jawaharlal Nehru Medical College and Hospital, Aligarh, India. A total of 70 patients diagnosed with COM were enrolled and divided into two groups. Group A (middle-aged COM group) included patients 41 to 60 years of age and Group B (younger COM group) consisted of patients 21 to 40 years of age. Patients were followed up for a period of approximately six to nine months to assess the audiological status evaluated at three, six, and nine months after surgery.RESULTSIt was found that after three, six, and nine months post-surgery, the difference in the mean audiological gain was not statistically significant, with p-values at 0.3034, 0.3271, and 0.2923, respectively. The audiological gain demonstrated a slight decrease over time in both groups.CONCLUSIONAudiological improvement, measured as the mean audiological gain, demonstrated a slight decrease over time in both groups. However, there was no significant difference in the improvement of the air-bone gap between middle-aged and younger patients.

100 Deals associated with Jawaharlal Nehru Medical College & Hospital

100 Translational Medicine associated with Jawaharlal Nehru Medical College & Hospital

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