A comparative study of effect of intrathecal hyperbaric Ropivacaine 0.75% vs hyperbaric Bupivacaine 0.5% for postoperative analgesia in Infraumblical surgeries - nil

Start Date07 Mar 2025

Sponsor / Collaborator

Jawaharlal Nehru Medical College & Hospital

CTRI/2024/09/074101 / Not yet recruitingPhase 2IIT

Efficacy of Individual Homeopathic Medicine in cases of Fibromyalgia; A Clinical, Randomized Placebo-controlled Trial Using Revised Fibromyalgia Impact Questionnaire. - nil

Start Date01 Nov 2024

Sponsor / Collaborator

Jawaharlal Nehru Medical College & Hospital

CTRI/2024/10/074743 / Not yet recruitingNot ApplicableIIT

TO COMPARE TOLERANCE TO OROGASTRIC FEEDING IN PRETERM NEONATES OF 28 TO 34 WEEKS OF GESTATIONAL AGE IN KANGAROO MOTHER CARE(KMC) POSITION VERSUS SUPINE POSITION HOSPITAL BASED RANDOMISED CONTROLLED TRAIL STUDY. - nil

Start Date15 Oct 2024

Sponsor / Collaborator

Jawaharlal Nehru Medical College & Hospital

100 Clinical Results associated with Jawaharlal Nehru Medical College & Hospital

0 Patents (Medical) associated with Jawaharlal Nehru Medical College & Hospital

Literatures (Medical) associated with Jawaharlal Nehru Medical College & Hospital

01 Dec 2024·Obesity Pillars

Bariatric surgery association with risk of recurrent stroke hospitalization among older stroke survivors with obesity: A national inpatient sample study (2016–2019)

Article

Author: Sunkara, Praveena ; Sundaram, Dakshin Meenashi ; Thompson-Edwards, Ashley ; Vanani, Samir ; Dhavapalani, Dhayashri ; Anand, Dharshana Prem ; Rajarajan, Srinishant ; Babu, Kalaivani ; Vasavada, Advait ; Mahadevan, Arankesh ; Desai, Rupak ; Reyaz, Nafisa ; Garikipati, Sushmitha

Background and aimsThe paucity of large-scale data exploring the effect of prior bariatric surgery on recurrent stroke outcomes in older individuals with obesity who survived a stroke led us to address the gap, with an emphasis on the risk of recurrent stroke and its trends.MethodsRetrospective analysis of the National Inpatient Sample data from 2016 to 2019. Older individuals with obesity who survived a stroke (>65 years) and had a recurrent acute ischemic stroke (AIS) hospitalization, with or without prior bariatric surgery (PBS), were identified using ICD-10 codes. Recurrent stroke trends, demographic characteristics, and comorbidities between the cohorts were compared.ResultsAnalyzing 643,505 older individuals with obesity who survived a stroke, we identified that 11,820 had undergone PBS. Both groups (no PBS vs. PBS) were predominantly female (59.7 % vs. 73.7 %), identified as white (76.5 % vs. 83.8 %), and covered by Medicare (91.7 % vs. 90.7 %). Diabetes, hyperlipidemia, prior myocardial infarction, and peripheral vascular diseases were more common in those without PBS. In contrast, tobacco use disorder, drug abuse, and valvular diseases were more common in those with PBS. There was no significant difference in the prevalence of hypertension between groups.Between 2016 and 2019, recurrent AIS hospitalizations were less frequent in the PBS group (4 %-2.9 %, p = 0.035) while remaining stable in the other group (4.4 %-4.2 %, p = 0.064). The risk of recurrent AIS hospitalization was less frequent in the PBS cohort (aOR: 0.77, 95 % CI: 0.60-0.98).ConclusionPBS in older individuals with obesity who survived a stroke was associated with a 23 % lower risk of recurrent AIS hospitalization with a decreasing trend of prevalence since 2016. These findings could influence clinical practice and contribute to developing secondary prevention strategies for recurrent stroke among these patients.

01 Sep 2024·Indian Journal of Surgical Oncology

Dysgerminoma with Syncytiotrophoblastic Giant Cells Associated with a Concurrent Ectopic Pregnancy

Article

Author: Saeed, Noora ; Aden, Durre ; Hassan, Mahboob ; Haiyat, Sadaf

BackgroundDysgerminomas constitute around 1-2% of all germ cell tumours. It is very very rare to have dysgerminoma with concurrent pregnancy with an incidence of 0.2-1 per 100,000 pregnancies. It is extremely difficult to conceive with no assisted reproductive interventions and carry it till completion with no complications in a concurrent dysgerminoma. Dysgerminoma has a characteristic specific histomorphology and is easy to diagnose. However, occasionally, syncytiotrophoblastic differentiation can be seen in dysgerminoma although it is a rare histopathological finding. Also, the raised serum B-HCG levels due to the syncytiotrophoblast giant cells seen can lead to a diagnostic dilemma.Clinical presentationHere we report a case of a 27-year-old 8-week pregnant female who came to the hospital with chief complaints of left-sided abdominal pain and a lump abdomen. Clinical and radiological examination revealed a left ovarian tumour of malignant aetiology with the presence of right ectopic pregnancy. A staging laparotomy with left salpingoophorectomy was performed and sent for histopathological examination. It was reported as dysgerminoma with syncytiotrophoblastic giant cells. The right fallopian tube showed products of conception. Finally, she was planned for adjuvant chemotherapy and serial B-HCG levels.SummaryThis case is reported not only just for its rare histopathological finding but also for the diagnostic dilemma it causes both to the surgeon as well as the pathologist. There are various factors which can act as prognosticators such as early suspicion of a tumor, radiological findings, surgery, histopathological examination, and oncology team.

01 Sep 2024·BMJ Case Reports

Primary adrenal insufficiency with normal male external genitalia in a boy with CYP11A1 deficiency

Article

Author: Kaivallyam Ramachandran, Sibi ; Moolath, Sahla ; Edavana, Shaju ; Alam, Ahmad

The first and rate-limiting step of steroid hormone biosynthesis is catalysed by mitochondrial cytochrome P450 side-chain cleavage enzyme (CYP11A1). CYP11A1 deficiency is commonly associated with adrenal insufficiency and, in 46 XY individuals, with variable degrees of differences in sex development (DSD). Here, we present a case report of a preadolescent male who presented to our emergency outpatient department in a state of decompensated shock necessitating ionotropic support. Further evaluation confirmed primary adrenal insufficiency. Subsequent clinical exome sequencing uncovered a compound heterozygous mutation in exons one and five of the CYP11A1 gene. This case highlights the varied presentation of CYP11A1 deficiency, showing that it can present as adrenal insufficiency without DSD.

100 Deals associated with Jawaharlal Nehru Medical College & Hospital

100 Translational Medicine associated with Jawaharlal Nehru Medical College & Hospital

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 24 Dec 2024

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Jawaharlal Nehru Medical College & Hospital

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 24 Dec 2024

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing