[Translation] A multicenter, randomized, active-drug and placebo-controlled phase Ib clinical trial evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of repeated doses of the investigational drug 1MW5011 (formerly RP901) tablets in patients with knee osteoarthritis.
主要目的:
(1)评估1MW5011片不同剂量和给药间隔下治疗膝骨关节炎的安全性和耐受性;
(2)评价1MW5011片在膝骨关节炎受试者的药代动力学、药效学特征。
[Translation] Main objectives:
(1) To evaluate the safety and tolerability of 1MW5011 tablets at different doses and dosing intervals for the treatment of knee osteoarthritis;
(2) To evaluate the pharmacokinetic and pharmacodynamic characteristics of 1MW5011 tablets in subjects with knee osteoarthritis.