Front Pharmaceutical PLC.

This study used healthy participants as research subjects, with flurbiprofen gel patch developed by Fuyuan Pharmaceutical Co., Ltd. as the test formulation and flurbiprofen gel patch manufactured by MIKASA SEIYAKU CO.,LTD KAKEGAWA FACTORY as the reference formulation. The absorption rate and extent of absorption of the two formulations in healthy participants were compared, and their bioequivalence was evaluated. The safety, skin reactivity, and adhesion of the test and reference formulations of flurbiprofen gel patch were observed in healthy Chinese participants.

This study used healthy participants as subjects. Ketoprofen gel patches (10 g of gel per patch (10 cm × 14 cm), containing 30 mg of ketoprofen) manufactured by Fukuhara Pharmaceutical Co., Ltd. were used as the test formulation. Ketoprofen gel patches (MOHRUS® Paps, 30 mg, 10 cm × 14 cm), manufactured by Hisamitsu Pharmaceutical Co., Ltd., were used as the reference formulation. The absorption rate and extent of absorption of the two formulations in healthy participants were compared, and their bioequivalence was evaluated. The safety, skin reactivity, and adhesion of the test and reference formulations of ketoprofen gel patches were observed in healthy Chinese participants.

Primary Objective: Using healthy participants as subjects, this study compared the pharmacokinetics of diclofenac diethylamine emulsion 2% (50 g: 1.0 g, based on diclofenac sodium) manufactured and licensed by Fuyuan Pharmaceutical Co., Ltd., as the test formulation, and the bioequivalence of diclofenac diethylamine emulsion manufactured by Haleon CH SARL and licensed by Haleon Schweiz AG (trade name: Voltaren®, specification: 2% (50 g: 1.0 g, based on diclofenac sodium)) as the reference formulation. Secondary Objectives: (1) To observe the safety of the test formulation diclofenac diethylamine emulsion and the reference formulation diclofenac diethylamine emulsion in healthy participants; (2) To evaluate the skin reactivity of the test formulation diclofenac diethylamine emulsion and the reference formulation diclofenac diethylamine emulsion in healthy participants.