Delving into the Latest Updates on Toa Gosei Co., Ltd. with Synapse

Overview

ABSTRACTThe chain‐end structure of the photopolymerized acrylate using benzophenone as an initiator was investigated as well as polymerization behavior. Dodecyl acrylate was used as a monomer in this study. Gelation occurred during ultraviolet (UV) irradiation, whereas a cross‐linker was not employed. Conversion‐time profile below gel point gave a linear first‐order plot suggesting that the steady‐state was held throughout polymerization. Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectra of the resultant polymer indicated that most polymers had an acryloyl group at one of the chain‐ends, while some polymers had an acryloyl group at each chain‐end. The cross‐linking reaction leading to gelation would have been caused by the subsequent copolymerization of the residual monomer with the latter polymer having two acryloyl groups. Dissolved oxygen in the monomer solution influenced the polymer structure giving hydroxyl group at chain‐end. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1545–1553

01 Jul 1997·Molecular and Cellular BiologyQ3 · BIOLOGY

Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis

Q3 · BIOLOGY

Article

Author: Kuwano, Michihiko ; Izumi, Hiroto ; Ono, Mayumi ; Suzuki, Hideo ; Shono, Tadahisa ; Yoshida, Shigeo ; Ishibashi, Tatsuro

Tumor necrosis factor alpha (TNF-alpha) is a macrophage/monocyte-derived polypeptide which modulates the expression of various genes in vascular endothelial cells and induces angiogenesis. However, the underlying mechanism by which TNF-alpha mediates angiogenesis is not completely understood. In this study, we assessed whether TNF-alpha-induced angiogenesis is mediated through TNF-alpha itself or indirectly through other TNF-alpha-induced angiogenesis-promoting factors. Cellular mRNA levels of interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and their receptors were increased after the treatment of human microvascular endothelial cells with TNF-alpha (100 U/ml). TNF-alpha-dependent tubular morphogenesis in vascular endothelial cells was inhibited by the administration of anti-IL-8, anti-VEGF, and anti-bFGF antibodies, and coadministration of all three antibodies almost completely abrogated tubular formation. Moreover, treatment with Sp1, NF-kappaB, and c-Jun antisense oligonucleotides inhibited TNF-alpha-dependent tubular morphogenesis by microvascular endothelial cells. Administration of a NF-kappaB antisense oligonucleotide almost completely inhibited TNF-alpha-dependent IL-8 production and partially abrogated TNF-alpha-dependent VEGF production, and an Sp1 antisense sequence partially inhibited TNF-alpha-dependent production of VEGF. A c-Jun antisense oligonucleotide significantly inhibited TNF-alpha-dependent bFGF production but did not affect the production of IL-8 and VEGF. Administration of an anti-IL-8 or anti-VEGF antibody also blocked TNF-alpha-induced neovascularization in the rabbit cornea in vivo. Thus, angiogenesis by TNF-alpha appears to be modulated through various angiogenic factors, both in vitro and in vivo, and this pathway is controlled through paracrine and/or autocrine mechanisms.

01 Jul 1994·Chemistry Letters

Synthesis of Oligosilanes by Electrolysis of Hydrosilanes

Author: Kimata, Yoshinori ; Satoh, Shin ; Kuriyama, Akira ; Suzuki, Hiroshi

AbstractThe novel electrochemical reaction of hydrosilane compounds was investigated for the synthesis of polysilanes. The product obtained by electrolysis of Methylphenylsilane 1a was an oligosilane of Mn = 454 (GPC) in 60% yield, which consisted of Si-Si bonds for the main chain. When diphenylsilane was electrolyzed in a similar manner as 1a, the major product was a dimer in 23% yield.

100 Deals associated with Toa Gosei Co., Ltd.

Login to view more data

100 Translational Medicine associated with Toa Gosei Co., Ltd.

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 30 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Other

1

Login to view more data