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Post hoc analysis of a study of the effect of improving urinary problems with foods containing Brazilian green propolis extract, pumpkin seed extract and cranberry extract in healthy women - Post hoc analysis of a study of the effect of improving urinary problems with foods containing Brazilian green propolis extract, pumpkin seed extract and cranberry extract in healthy women

Start Date05 Jul 2024

Sponsor / Collaborator

Yamada Bee Farm Corp.

JPRN-UMIN000054919

/ SuspendedNot Applicable

Evaluation of the Effect of Honey Intake on Improving Bowel Movements in Individuals with a Tendency towards Constipation - Evaluation of the Effect of Honey Intake on Improving Bowel Movements in Individuals with a Tendency towards Constipation

Start Date24 Jun 2024

Sponsor / Collaborator

Yamada Bee Farm Corp.

JPRN-UMIN000054124

/ CompletedNot Applicable

Evaluation of the skin penetration of cosmetics containing honeybee products - Evaluation of the skin penetration of cosmetics containing honeybee products

Start Date20 May 2024

Sponsor / Collaborator

Yamada Bee Farm Corp.

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100 Clinical Results associated with Yamada Bee Farm Corp.

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0 Patents (Medical) associated with Yamada Bee Farm Corp.

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32

Literatures (Medical) associated with Yamada Bee Farm Corp.

25 Jun 2025·The Journal of the Kyushu Dental Society

Function of Food Components on Bone and Skeletal Muscle Metabolism

Author: Shirakawa, Tomohiko ; Okumura, Nobuaki ; Kokabu, Shoichiro ; Yamashita Takeuchi, Sachiko ; Matsubara, Takuma ; Okamoto, Hideto

21 Feb 2025·ACS Food Science & Technology

Pharmacokinetic Profiles of Melinjo Seed Extract Components in Rats

Author: Ikuta, Tomoki ; Shuto, Tsuyoshi ; Suico, Mary Ann ; Kishimoto, Tomoki ; Yamaga, Masayuki ; Tani, Hiroko

Melinjo (Gnetum gnemon L.) seeds are rich in resveratrol (RES) and its dimers, gnetin C and gnemonoside A.They have various pharmacol. benefits, and antioxidant and anti-inflammatory properties; however, their pharmacokinetics, especially in animal models, must be better understood.This study aimed to elucidate the pharmacokinetics of melinjo seed extract (MSE) components in rats.Plasma samples were collected up to 24 h after intergastric administration of MSE (1000 mg/kg), gnetin C, or gnemonoside A (51 μmol/kg each).RES was present as conjugates, with maximum plasma concentration (1065 nM) achieved at 6 h postadministration of MSE.The plasma concentrations of gnetin C and gnemonoside A following MSE administration were sustained, and their absorption rates, based on the AUC-dose relationship, reached 13.7 and 4.8%, resp., and higher than that of each standard alone.These findings indicate that MSE enhances the absorption of RES and its derivatives, potentially supporting their therapeutic applications and functional foods.

01 Jan 2025·Experimental Animals

Royal jelly reduced non-rapid eye movement sleep fragmentation and restored sleep stability in diet-induced obese mice

Article

Author: Tanaka, Shun ; Sugiura, Chiaki ; Sato, Mao ; Okumura, Nobuaki ; Terao, Akira

Royal jelly (RJ) is recognized due to its high nutritional value and potential health benefits. Previous research showed that RJ supplementation decreased fat accumulation, resulting in weight loss and improvements in hyperglycemia and insulin resistance in high-fat diet (HFD)-induced obese mice. To expand the weight-reducing properties of RJ, this study aimed to investigate the effects of RJ supplementation on HFD-induced obese mice with impaired sleep stabilization. Over a 20-week period, the C57BL/6J mice were divided into the following dietary groups: normal diet (ND), ND supplemented with 5% lyophilized RJ powder (ND+RJ), HFD, and HFD supplemented with 5% lyophilized RJ powder (HFD+RJ) groups. Compared with the HFD group, the HFD+RJ group exhibited a significant reduction in body weight via a decrease in fat mass. Moreover, much like the ND group, the HFD+RJ group demonstrated improvements in the fragmentation of non-rapid eye movement (NREM) sleep and wakefulness. These processes contributed to the reestablishment of sleep/wake continuity and restored the overall stability of sleep. In contrast, the ND+RJ and ND groups exhibited a similar sleep/wake architecture. Thus, RJ supplementation in the ND demonstrated no substantial effect on sleep/wake. According to these findings, dietary RJ improves the sleep/wake architecture and restores sleep stability. Hence, RJ is a promising dietary component for addressing obesity and restoring sleep stability.

100 Deals associated with Yamada Bee Farm Corp.

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100 Translational Medicine associated with Yamada Bee Farm Corp.

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