Sichuan Difit Pharmaceutical Co Ltd.

To investigate whether there are differences in the extent and rate of absorption between the test preparation vonoprazan fumarate tablets (Sichuan Difit Pharmaceutical Co., Ltd., specification: 20 mg) and the reference preparation vonoprazan fumarate tablets (trade name: Walker, Takeda Pharmaceutical Company Limited., specification: 20 mg) taken orally on an empty stomach and after a meal in healthy subjects, to evaluate the bioequivalence of the test preparation and the reference preparation when administered on an empty stomach and after a meal, and to observe the safety of the test preparation and the reference preparation in healthy subjects.

A randomized, open, two-period crossover, single oral trial design was used to compare the differences in absorption extent and absorption rate of ursodeoxycholic acid capsules (specification: 0.25 g) provided by Sichuan Difit Pharmaceutical Co., Ltd. and ursodeoxycholic acid capsules (trade name: Ursofalk®/Ursofalk®; specification: 250 mg) produced by Dr. Falk Pharma GmbH (licensed by Losan Pharma GmbH) in healthy Chinese people under fasting and postprandial administration conditions, and to evaluate the safety of ursodeoxycholic acid capsules (specification: 0.25 g) provided by Sichuan Difit Pharmaceutical Co., Ltd.

Main purpose: To compare the differences in absorption degree and speed of single oral administration of Moxifloxacin Hydrochloride Tablets (Specification: 0.4 g) produced by Jilin Sihuan Pharmaceutical Co., Ltd. commissioned by Sichuan Difit Pharmaceutical Co., Ltd. and Moxifloxacin Hydrochloride Tablets (Trade Name: Avelox®; Specification: 0.4 g) certified by Bayer Vital GmbH in healthy people under fasting and fed conditions, and to evaluate the bioequivalence of the two preparations when taken orally under fasting and fed conditions. Secondary purpose: To evaluate the safety of single oral administration of Moxifloxacin Hydrochloride Tablets (Specification: 0.4 g) produced by Jilin Sihuan Pharmaceutical Co., Ltd. commissioned by Sichuan Difit Pharmaceutical Co., Ltd. and Moxifloxacin Hydrochloride Tablets (Trade Name: Avelox®; Specification: 0.4 g) certified by Bayer Vital GmbH under fasting and fed conditions.