GC Cell Corp.

SEOUL, South Korea, April 21, 2025 /PRNewswire/ -- DAAN Biotherapeutics, a leading innovative drug development company specializing in T-Cell receptor (TCR)-based therapies, has signed an exclusive licensing agreement with GC Cell, a gene and cell therapy firm, for the tumor antigen-specific antibody sequence. The agreement grants GC Cell exclusive rights to utilize DAAN Biotherapeutics' antibody sequence in the research and development of CAR-T (chimeric antigen receptor T cell) and CAR-NK (chimeric antigen receptor natural killer cell) therapies. Continue Reading DAAN Biotherapeutics logo The antibody at the center of the agreement targets a tumor antigen that is highly overexpressed in major solid cancers, including lung and colorectal cancers, and this antigen has continually been used by several pharmaceutical companies in the development of next-generation cancer therapies. The antibody provided by DAAN Biotherapeutics offers enhanced specificity compared to existing antibodies, allowing itself to be positioned as a promising candidate for cell therapies. This increased precision is expected to significantly reduce side effects while improving therapeutic outcomes, making it a more effective option than existing treatments. The combination of GC Cell's advanced CAR cell-therapy technology and DAAN Biotherapeutics' antibody technology is expected to significantly enhance the effectiveness of CAR cell therapies. The licensing deal includes an upfront payment, milestone payments tied to development and commercialization stages, and royalties based on future sales. Specific financial and contractual details remain confidential to safeguard proprietary technologies and business strategies. Both companies view this collaboration as a pivotal step toward the commercialization of cell therapies for the treatment of solid tumors. Byoung-Chul Cho, MD, the CEO of DAAN Biotherapeutics, stated, "We will continue to innovate our technologies to develop cancer treatments that will change the lives of patients." SOURCE DAAN Biotherapeutics WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

YONGIN, South Korea I March 12, 2025 I GC Cell (KRX:144510), under the leadership of CEO Sungyong Won, announced today the initiation of its domestic Phase 1 clinical trial for GCC2005 (AB‑205), a novel CD5 CAR‑NK cell therapy. This “first patient dosing” marks a critical milestone in the company’s collaboration with its ex-APAC partner Artiva Biotherapeutics, as we advance the development of this innovative treatment targeting relapsed or refractory NK and T‑cell malignancies. With GCC2005, GC Cell is striving to fulfill a significant unmet need in oncology. T‑cell lymphomas, which often arise in extranodal lymphoid tissues, are highly aggressive and generally exhibit a poorer prognosis than their B‑cell counterparts with limited treatment options. Aimed at expanding possibilities for NK‑cell therapies, GCC2005 is an allogeneic cell therapy product manufactured using umbilical cord blood–derived NK cells. Engineered to target the CD5 marker—which is highly expressed on T‑cell lymphomas—GCC2005 co‑expresses a chimeric antigen receptor (CAR) alongside interleukin‑15 (IL‑15). This dual expression is designed to enhance the persistence and anti‑tumor efficacy of NK cells—effectively addressing a common limitation of conventional NK-cell therapies. The ongoing Phase 1 trial (ClinicalTrials.gov Identifier: NCT06699771) will enroll up to approximately 48 patients diagnosed with relapsed or refractory NK and T‑cell malignancies. The primary objectives of the study are to evaluate the safety and tolerability of GCC2005, the maximum tolerated dose (MTD), and the recommended Phase 2 dose (RP2D). “The initiation of this Phase 1 trial marks a significant step toward expanding treatment options for patients with T-cell lymphomas,” said Dr. Won Seog Kim of Samsung Medical Center, the lead investigator of the study. “With this first patient dosing, we anticipate contributing to both the advancement of CAR-NK therapies and the expansion of this emerging treatment landscape.” Preclinical efficacy data presented last year at the American Association for Cancer Research (AACR) and the T Cell Lymphoma Forum (TCLF) highlighted GCC2005’s potent ability to kill tumor cells and improve in vivo persistence. These promising results have bolstered expectations that GCC2005 could become a global first‑in‑class therapeutic option for T‑cell lymphoma. In recognition of its innovative potential, GCC2005 has also been selected by a Korea Drug Development Fund program aimed at promoting global market entry and strategic partnerships in drug development. “Building on our robust preclinical results, we are excited to commence the Phase 1 clinical trial of GCC2005. This study represents an important step toward providing a new treatment option for patients with relapsed or refractory NK and T‑cell malignancies,” said a GC Cell representative. “Our collaboration with Artiva Biotherapeutics and the recognition received through national support programs further validate our commitment to advancing breakthrough therapies in this challenging area.” About GC Cell GC Cell is a pioneering biopharmaceutical company dedicated to developing innovative cellular therapies for the treatment of hematologic malignancies and other challenging diseases. With a focus on next‑generation immuno‑oncology, GC Cell is committed to addressing significant unmet medical needs through cutting‑edge research and strategic global partnerships. SOURCE: GC Cell

Yongin, [2025.03.13] – GC Cell (KRX:144510), under the leadership of CEO Sungyong Won, announced today the initiation of its domestic Phase 1 clinical trial for GCC2005 (AB‑205), a novel CD5 CAR‑NK cell therapy. This “first patient dosing” marks a critical milestone in the company’s collaboration with its ex-APAC partner Artiva Biotherapeutics, as we advance the development of this innovative treatment targeting relapsed or refractory NK and T‑cell malignancies. With GCC2005, GC Cell is striving to fulfill a significant unmet need in oncology. T‑cell lymphomas, which often arise in extranodal lymphoid tissues, are highly aggressive and generally exhibit a poorer prognosis than their B‑cell counterparts with limited treatment options. Aimed at expanding possibilities for NK‑cell therapies, GCC2005 is an allogeneic cell therapy product manufactured using umbilical cord blood–derived NK cells. Engineered to target the CD5 marker—which is highly expressed on T‑cell lymphomas—GCC2005 co‑expresses a chimeric antigen receptor (CAR) alongside interleukin‑15 (IL‑15). This dual expression is designed to enhance the persistence and anti‑tumor efficacy of NK cells—effectively addressing a common limitation of conventional NK-cell therapies. The ongoing Phase 1 trial (ClinicalTrials.gov Identifier: NCT06699771) will enroll up to approximately 48 patients diagnosed with relapsed or refractory NK and T‑cell malignancies. The primary objectives of the study are to evaluate the safety and tolerability of GCC2005, the maximum tolerated dose (MTD), and the recommended Phase 2 dose (RP2D). “The initiation of this Phase 1 trial marks a significant step toward expanding treatment options for patients with T-cell lymphomas,” said Dr. Won Seog Kim of Samsung Medical Center, the lead investigator of the study. “With this first patient dosing, we anticipate contributing to both the advancement of CAR-NK therapies and the expansion of this emerging treatment landscape.” Preclinical efficacy data presented last year at the American Association for Cancer Research (AACR) and the T Cell Lymphoma Forum (TCLF) highlighted GCC2005’s potent ability to kill tumor cells and improve in vivo persistence. These promising results have bolstered expectations that GCC2005 could become a global first‑in‑class therapeutic option for T‑cell lymphoma. In recognition of its innovative potential, GCC2005 has also been selected by a Korea Drug Development Fund program aimed at promoting global market entry and strategic partnerships in drug development. “Building on our robust preclinical results, we are excited to commence the Phase 1 clinical trial of GCC2005. This study represents an important step toward providing a new treatment option for patients with relapsed or refractory NK and T‑cell malignancies,” said a GC Cell representative. “Our collaboration with Artiva Biotherapeutics and the recognition received through national support programs further validate our commitment to advancing breakthrough therapies in this challenging area.” About GC Cell GC Cell is a pioneering biopharmaceutical company dedicated to developing innovative cellular therapies for the treatment of hematologic malignancies and other challenging diseases. With a focus on next‑generation immuno‑oncology, GC Cell is committed to addressing significant unmet medical needs through cutting‑edge research and strategic global partnerships.