[Translation] A dose-finding, dose-expansion phase Ib/II clinical trial evaluating oral HTMC0435 tablets in combination with temozolomide in patients with relapsed small cell lung cancer
主要目的:评价HTMC0435片联合替莫唑胺在复发性小细胞肺癌患者中的安全性和耐受性;探索最大耐受剂量;探索潜在适应症的初步疗效。 次要目的:考察HTMC0435片联合替莫唑胺在复发性小细胞肺癌患者中的药代动力学特征。
[Translation] Main purpose: To evaluate the safety and tolerability of HTMC0435 tablets combined with temozolomide in patients with recurrent small cell lung cancer; to explore the maximum tolerated dose; to explore the preliminary efficacy of potential indications. Secondary objective: To investigate the pharmacokinetics of HTMC0435 tablets combined with temozolomide in patients with recurrent small cell lung cancer.