The objective of this paper is to study the process for extracting flavone compounds from hawthorn leaves.The extraction rate of total flavones compounds were used as indicator, the process was optimized for extracting flavones compounds from hawthorn leaves through single factor experiment and orthogonal test and design.The results showed that there is interaction among concentration of solvent, extraction temperature, extraction times and extraction times on extraction of flavones compounds from hawthorn leaves.The optimum tech. conditions after optimization the extraction temperature is 80°, concentration of solvent is 60%, extraction time is 3h, extraction times is 3.The results of single factor experiment and orthogonal test shows that the established model is reasonable.