Beijing Shenlanhai Biological Medicine Technology Co Ltd

Primary objective: To observe the pharmacokinetic characteristics of the test preparation Topiramate Tablets (Specification: 60 mg; Manufacturer: Ruiyang Pharmaceutical Co., Ltd.) and the reference preparation Topiramate Tablets (Trade name: Topiloric; Specification: 60 mg; Licensee: Fuji Pharmaceutical Co., Ltd.) after a single oral administration in the fasting/postprandial state in healthy Chinese subjects, and to preliminarily evaluate the bioequivalence of the two preparations in the fasting/postprandial state. Secondary objective: To observe the safety of the test preparation Topiramate Tablets and the reference preparation Topiramate Tablets (Topiloric) in healthy Chinese subjects

To study the pharmacokinetic characteristics of avanafil tablets after single and multiple oral administration and the effects of food in healthy Chinese male subjects, explore the characteristics of drug absorption, distribution, metabolism and elimination in healthy men, provide research data for the registration application of avanafil tablets, provide reference basis for the dosing regimen of confirmatory clinical trials of avanafil tablets, and provide experimental basis for determining the clinical dosing regimen of avanafil tablets.

To study the pharmacokinetic characteristics of topiramate tablets after single and multiple oral administration and the effects of food in healthy Chinese subjects, explore the characteristics of drug absorption, distribution, metabolism and elimination in healthy people, provide research data for the registration application of topiramate tablets, provide reference basis for the dosing regimen of confirmatory clinical trials of topiramate tablets, and provide experimental basis for determining the clinical dosing regimen of topiramate tablets.