[Translation] A first-in-human phase I study evaluating the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of SYN818, a DNA polymerase theta [POLQ] inhibitor, as a single agent in patients with locally advanced or metastatic solid tumors
评价 SYN818 单药治疗在晚期或转移性实体瘤患者中的安全性和耐受性,可能包括确定最大耐受剂量(MTD)。
[Translation] Evaluate the safety and tolerability of SYN818 monotherapy in patients with advanced or metastatic solid tumors, which may include determining the maximum tolerated dose (MTD).