Delving into the Latest Updates on Ayerst Laboratories, Inc. with Synapse

Overview

Tags

Immune System Diseases

Digestive System Disorders

Respiratory Diseases

Small molecule drug

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Immune System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	4
Chemical drugs	1

Top 5 Target	Count

NET(Norepinephrine transporter)	1
PGE2(Prostaglandin E2)	1
H2 receptor(Histamine H2 receptor)	1
α-adrenergic receptor(Alpha adrenergic receptor)	1
ADRA1(Adrenergic receptor alpha-1)	1

(±)-AY-22469 (I) [50266-09-6] and its ent [50454-71-2] and nat isomer [33813-84-2] inhibited gastric acid secretion in rats although the volume of gastric juice was unchanged; the ent isomer (ED50 mg/kg) was 2.8 times as potent as the nat isomer.The incidnce of diarrhea in mice was low with both isomers (25% at 240 mg/kg).

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

Blockade of noradrenaline uptake and inhibition of gastric acid secretion by 2-[p-chlorophenyl-2-(pyridyl)-hydroxymethyl] imidazoline maleate (Sch-12650)

Q3 · MEDICINE

Article

Author: Lippmann, W

The i.p. administration of the title compound (I, 1.25-10.0 mg/kg) inhibited the uptake of noradrenaline-3H by rat heart by 14-72% but did not cause its increase release.I was similar in potency to imipramine, as the noradrenaline-3H level was decreased to ∼50% by ∼4 mg/kg of either compoundI (5.0 mg/kg, i.p.) decreased gastric acid secretion by 65%, whereas imipramine (5.0 mg/kg) decreased gastric acid secretion by 71%.In pentagastrin-induced gastric acid secretion, I (5.0 mg/kg, i.p.) inhibited gastric acid secretion by 88%, a similar inhibition being noted with imipramine (10 mg/kg, i.p.).

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

Diethyldithiocarbamate and structurally-related compounds and the uptake and release of noradrenaline in the heart of the rat

Q3 · MEDICINE

Article

Author: Lloyd, K ; Lippmann, W

Pretreatment (125 mg/kg, i.p.) with disulfiram and diethyldithiocarbamate, inhibitors of cardiac dopamine β-hydroxylase, as well as with the structurally related compounds, ethyldithiocarbamate, dimethyldithiocarbamate, tetramethylthiuram disulfide, and tetramethylthiuram monosulfide, had no significant effect on the uptake, short-term storage, or release of exogenously administered tritiated noradrenaline in the rat heart.

100 Deals associated with Ayerst Laboratories, Inc.

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100 Translational Medicine associated with Ayerst Laboratories, Inc.

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Pipeline

Pipeline Snapshot as of 27 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

5

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

AY-22093 ( PGE2 )	Bronchial Spasm More	Preclinical
Atiprosin ( α-adrenergic receptor )	Hypertension More	Preclinical
AY-29315 ( H2 receptor )	Peptic Ulcer More	Preclinical
Tandamine ( NET )	Depressive Disorder More	Preclinical
AY-30191 ( ADRA1 )	-	Preclinical