Yunnan Phytopharmaceutical Co. Ltd.

Sixteen compounds including twelve previously undescribed sesquiterpenes were isolated from Salacia obovatilimba. Based on HRESIMS, IR, NMR and electronic circular dichroism (ECD) spectroscopic analysis, the previously undescribed compounds were characterized as twelve undescribed dihydro-β-agarofuran sesquiterpenoids (compounds 1-12). The structures of compounds 1 and 6 were confirmed by single-crystal X-ray diffraction. All compounds were assayed for their inhibitory effect on hSGLT2 in vitro, results suggested compounds 11 and 13 exhibited significant hSGLT2 inhibitory activity, with IC₅₀ values of 11.9 and 9.45 nM, respectively. The probable binding potency were predicted through molecular docking by accurate models of protein-ligand complex.

Aconitum vilmorinianum Kom. is a perennial herb from the genus Aconitum in the Ranunculaceae family, notable for its high toxicity yet common use in treating bruises. It holds significant medicinal value among several ethnic minorities in China, including the Yi, Hani, Naxi, and Pumi, due to its unique biological attributes and widespread traditional uses.

This review analyzes A. vilmorinianum's biological characteristics, traditional uses, ethnopharmacology, chemical composition, pharmacological activities, toxicity, endophyte isolation, processing methods, and artificial-cultivation techniques.

Information on A. vilmorinianum was gathered from globally recognized electronic databases including Web of Science, PubMed, Science Direct, Springer Link, ACS, and CNKI.

Eighty-seven chemical components such as diterpenoid alkaloids, glycosides, and flavonoids, have been isolated and identified from A. vilmorinianum. These compounds display multiple toxicities, including cardiotoxicity, hepatotoxicity, and nephrotoxicity. Experimental studies have demonstrated that processing reduces toxicity while preserving efficacy.

The compounds yunaconitine and bulleyaconitine in A. vilmorinianum are effective in treating inflammation and various pain types. Appropriate processing and formulation significantly reduce their toxicity and increase the plant's therapeutic efficacy.

Our current adsorbents have a limited capacity for adsorbing Panax notoginseng saponins (PNS).To address this issue, we synthesized a novel bioadsorbent called rosin polymer/diatomite microspheres (RPM/DT).This was done by doping diatomite (DT), an inorganic substance, with rosin-based organic compoundsPNSs adsorption capacity on RPM/DT is 427.96 mg.g^-1, which is 6.5 times that of current adsorbents.RPM, without DT, displayed only 125.10 mg.g^-1.This considerable difference in adsorption capacity can be attributed to the phys. incorporation of DT into and onto the surface of RPM/DT.In addition, the incorporation plays a crucial role in creating pores, resulting in a remarkable increase in the sp. surface area of RPM/DT (734.55 m².g^-1), surpassing that of RPM (405.17 m².g-1).Addnl., using RPM/DT resulted in a significant increase in PNS purity, rising from 48.47% to 86.16%.We investigated the isotherm, kinetics, and thermodn. properties of PNS on RPM/DT and found that the adsorption is spontaneous, endothermic, and predominantly chemisorptive.Quantum chem. calculations further revealed the adsorption mechanism of PNS on RPM/DT.The functional monomer mols. RPM/DT interacted with Rb1, involving van der Waals forces, H-bonds, and intermol. electrostatic interactions.In summary, RPM/DT is an efficient and reusable biosorbent with the potential to be used in the separation and enrichment of PNS from crude solutions