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主要研究目的是在健康男性和女性受试者中于空腹情况下评价马来酸氯苯那敏片和Chlor-Tripolon®的吸收速度和吸收程度，评价两制剂间是否具有生物等效性。次要研究目的是评估受试制剂马来酸氯苯那敏片和参比制剂Chlor-Tripolon®在中国健康受试者中的安全性。

[Translation]

The primary study objective is to evaluate the absorption rate and extent of chlorpheniramine maleate tablets and Chlor-Tripolon® in healthy male and female subjects under fasting conditions, and to evaluate whether the two preparations are bioequivalent. The secondary study objective is to evaluate the safety of the test preparation chlorpheniramine maleate tablets and the reference preparation Chlor-Tripolon® in healthy Chinese subjects.

Start Date13 Nov 2018

Sponsor / Collaborator

Yunnan Phytopharmaceutical Co. Ltd.

100 Clinical Results associated with Yunnan Phytopharmaceutical Co. Ltd.

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0 Patents (Medical) associated with Yunnan Phytopharmaceutical Co. Ltd.

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7

Literatures (Medical) associated with Yunnan Phytopharmaceutical Co. Ltd.

Yaowu Fenxi Zazhi

HPLC determination of palmatine hydrochloride in its tablets

Author: Zhu, Hongtao ; Mei, Yan ; Zhou, Zhihong ; Liao, Xiaochun ; Huang, Pilan

A specific HPLC method was developed for the measurement of palmatine hydrochloride in its tablets.Anal. was carried out on Shimadzu LC-2010A HPLC.The separation was performed on Shim-pack VP-ODS column (4.6 mm, 4.6 × 150 mm), with methanol-THF-0.1% phosphoric acid (35:0.1:65) as mobile phase, and the flow rate was 1.0 mL/min^-1 and the detective wavelength was 350 nm.A good linear relationship was found within the range of 0.2-1.4 μg.The mean recovery was 98.7% while RSD was 0.90% (n = 5).This method is rapid, simple, and accurate, and suitable for the quality control of the drug.

Zhongcaoyao

A new triterpene saponin from roots of Dolichos falcata

Author: Wu, Zheng-cai ; Xie, Zhong-lang ; Teng, Li-bing ; Huang, Chun-qiu

Objective To study the chem. constituents from the roots of Dolichos falcata.Methods The chem. constituents were isolated by column chromatog. with silica gel and Sephadex LH-20.Their structures were identified on the basis of spectroscopic anal.Results Three compounds were isolated from the roots of D. falcata and identified as 3β,23-dihydroxy-2-oxoolean-12-en-28-dioic acid 3-O-β-D-glucopyranoside (1), 3β-hydroxyolean-12-en-23,28-dioic acid 3-O-β-Dglucopyranoside (2), and 2β,3β-dihydroxyolean-12-en-23,28-dioic acid 3-O-β-D-glucopyranoside (3).Conclusion Compound 1 is a new triterpene glycoside named doliroside C and compound 2 is isolated from this plant for the first time.

Yaowu Fenxi Zazhi

HPLC determination of scutellarin in Breviscapus granules

Author: Zhou, Zhihong ; Zheng, Liping ; Huang, Chunqiu ; Xiong, Yi ; Liao, Xiaochun

To establish an HPLC method for the determination of scutellarin in Breviscapus granules, the chromatog. column of Shimadzu VP-ODS was used.The mobile phase consisted of methanol-tetrahydrofuran-0.1% phosphoric acid (15:15:70), and the flow rate was 1.0 mL·min^-1.The detection wave-length was 335 nm.The linear range of scutellarin was 0.125-0.875 μg (r=0.9993).The average recovery of assay was 98.1% with RSD 1.3%.The HPLC method is simple and reliable for the simultaneously determination of scutellarin in Breviscapus granules.

100 Deals associated with Yunnan Phytopharmaceutical Co. Ltd.

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100 Translational Medicine associated with Yunnan Phytopharmaceutical Co. Ltd.

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Pipeline

Pipeline Snapshot as of 08 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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