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Inactive Indication- |
Drug Highest PhasePhase 1 |
First Approval Ctry. / Loc.- |
First Approval Date- |
/ Not yet recruitingPhase 1 一项评价TM471-1胶囊在健康成年受试者中单次、多次剂量递增口服给药的安全性、耐受性、药代动力学、药效学及食物影响的Ia期临床试验
[Translation] A Phase Ia clinical trial to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and food effects of single and multiple ascending doses of TM471-1 capsules in healthy adult subjects
主要研究目的:
评价中国健康成年受试者接受单、多次TM471-1胶囊给药后的安全性和耐受性;
次要研究目的:
(1)评估中国健康成年受试者接受单、多次TM471-1胶囊给药后的药代动力学(PK)特征;
(2)评估中国健康成年受试者在空腹及高脂餐条件下单次给药后食物对TM471-1胶囊PK参数的影响;
探索性研究目的:
(1)探索中国健康成年受试者接受单、多次TM471-1胶囊口服给药后的药效学(PD)指标及其与PK参数的关系;
(2)探索TM471-1胶囊口服给药后血浆中的可能代谢产物。
[Translation] Main study objectives:
To evaluate the safety and tolerability of TM471-1 capsules after single and multiple administrations in healthy Chinese adult subjects;
Secondary study objectives:
(1) To evaluate the pharmacokinetic (PK) characteristics of TM471-1 capsules after single and multiple administrations in healthy Chinese adult subjects;
(2) To evaluate the effect of food on the PK parameters of TM471-1 capsules after single administration in healthy Chinese adult subjects under fasting and high-fat meal conditions;
Exploratory study objectives:
(1) To explore the pharmacodynamic (PD) indicators and their relationship with PK parameters after single and multiple oral administrations of TM471-1 capsules in healthy Chinese adult subjects;
(2) To explore the possible metabolites in plasma after oral administration of TM471-1 capsules.
评价BTK抑制剂TM471-1胶囊在B细胞非霍奇金淋巴瘤(NHL)患者中的安全性、耐受性、药代动力学和初步药效的I期临床试验
[Translation] A Phase I clinical trial to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of BTK inhibitor TM471-1 capsules in patients with B-cell non-Hodgkin lymphoma (NHL)
剂量爬坡阶段:主要目的: (1)观察口服TM471-1胶囊单药在复发或难治B细胞NHL患者中的安全性和耐受性;(2)探索复发或难治B细胞NHL患者口服TM471-1胶囊单药的最大耐受剂量(maximal tolerated dose,MTD),II期推荐剂量(recommend phase 2 dose,RP2D)和剂量限制性毒性(dose-limiting toxicity,DLT)。次要目的:(1)评估TM471-1胶囊的药代动力学(pharmacokinetics,PK)特征;(2)评估TM471-1胶囊的药效学(pharmacodynamics,PD)特征; (3)初步观察TM471-1胶囊单药的抗肿瘤活性。
剂量扩展阶段:主要目的:评估TM471-1胶囊单药的有效性。次要目的:(1)评估TM471-1胶囊单药的安全性和耐受性;(2)探索TM471-1胶囊在脑脊液中的分布。
[Translation] Dose escalation phase: Primary objectives: (1) To observe the safety and tolerability of oral TM471-1 capsules alone in patients with relapsed or refractory B-cell NHL; (2) To explore the maximum tolerated dose (MTD), recommended phase 2 dose (RP2D) and dose-limiting toxicity (DLT) of oral TM471-1 capsules alone in patients with relapsed or refractory B-cell NHL. Secondary objectives: (1) To evaluate the pharmacokinetic (PK) characteristics of TM471-1 capsules; (2) To evaluate the pharmacodynamic (PD) characteristics of TM471-1 capsules; (3) To preliminarily observe the anti-tumor activity of TM471-1 capsules alone.
Dose expansion phase: Primary objectives: To evaluate the efficacy of TM471-1 capsules alone. Secondary objectives: (1) to evaluate the safety and tolerability of TM471-1 capsules alone; (2) to explore the distribution of TM471-1 capsules in cerebrospinal fluid.
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