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Overview

AbstractObjectivesThe purpose of this study was to evaluate and compare the palatability of 10 formulations (the original manufacturer's formulation and nine generics) of amlodipine orally disintegrating tablets (ODTs) by means of human gustatory sensation testing, disintegration/dissolution testing and the evaluation of bitterness intensity using a taste sensor.MethodsInitially, the palatability, dissolution and bitterness intensity of the ODTs were evaluated in gustatory sensation tests. Second, the disintegration times of the ODTs were measured using the OD-mate, a newly developed apparatus for measuring the disintegration of ODTs, and lastly, the bitterness intensities were evaluated using an artificial taste sensor.Key findingsUsing factor analysis, the factors most affecting the palatability of amlodipine ODTs were found to be disintegration and taste. There was high correlation between the disintegration times of the 10 amlodipine ODTs estimated in human gustatory testing and those found using the OD-mate. The bitterness intensities of amlodipine ODTs 10, 20 and 30 s after starting the conventional brief dissolution test and the values determined by the taste sensor were highly correlated with the bitterness intensities determined in gustatory sensation testing.ConclusionsThe OD-mate and the taste sensor may be useful for predicting the disintegration and bitterness intensity of amlodipine ODTs in the mouth.

Fragrance Journal

An active cosmetic ingredient with skin-barrier reinforcing efficacy valorised from environmentally harmful algal blooms

Author: Watanabe, Yuki ; Alexander, Simone

Every year, the picturesque beaches of Brittany, France are assaulted by "Green Tides".Increased ocean temperature resulting from Global Warming and fertilizer run-off from farms causes blooms of a small, green seaweed Ulva lactuca Armoricana.As this seaweed rots, sulfated polysaccharides in the cell wall are converted to hydrogen sulfide: a poisonous gas.This causes numerous environmental and economic problems for the region.ODYCEA, a local Brittany expert in seaweed technol., valorised this seaweed into the active cosmetic ingredient JADE ALGA.They discovered that the cell wall' s ulvan polysaccharides allow the seaweed to withstand the dehydration and rehydration stress of its intertidal niche.ODYCEA then demonstrated that JADE ALGA has a similar barrier-reinforcing efficacy on human skin.JADE ALGA boosts the expression cornified envelope factors, increases skin cell turnover, promotes barrier function, and improves appearance.In 2021, JADE ALGA won a bronze award in the Environmental Category at CITE Japan.

Fragrance Journal

SEALIFT and GALACTEANE with excellent antivirus and anti-pollution material

Author: Watanabe, Hiroki

Introducing SEALIFT (trademark) and GALACTEANE (trademark), which are red algae extract products with anti-pollution and anti-virus effects, manufactured by Odesia of France.SEALIFT and GALACTEANE are oxidatively composed of galactan and carrageenan having excellent thickening effect and film-forming property, interacts with the skin and hair, and forms a solid film layer.The water-soluble polymer film interacts with the fine particles, and after rinsing, the fine particles are quickly removed together with the water-soluble polymer.After the theory, it binds to pos. charged pollution substances (fine particles, heavy metals, etc.) and viruses (herpes simplex, influenza, dengue), and plays a role in preventing contact with the skin.Compared to the untreated group, the SEALIFT treated group removed 62% of the iron oxide coating amount (MP) before rinsing and 36% after rinsing, reducing MP adhesion by 91% in total.Using bleached hair bundles, the 3% GALACTEANE treated group can remove 98% of iron oxide fine particles compared to the untreated group before rinsing.In conclusion, the red algae extract for improving anti-pollution effect and anti-virus effect.

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