Guangzhou Kanghe Pharmaceutical Co., Ltd.

Main purpose: Based on the relevant provisions of bioequivalence test, the test preparation of doxycycline hydrochloride tablets (100mg (calculated as C22H24N2O8)) produced by Guangzhou Kanghe Pharmaceutical Co., Ltd. was compared with the reference preparation of doxycycline hydrochloride tablets (trade name: Vibramycin, specification: 0.1g (calculated as C22H24N2O8)) held by Pfizer Japan Inc. to conduct a bioequivalence test to compare the bioequivalence of the two preparations under fasting and postprandial conditions. Secondary purpose: Evaluate the safety of a single oral dose of the test preparation (doxycycline hydrochloride tablets, T) and the reference preparation (Vibramycin, R) in healthy adult subjects in China.