Delving into the Latest Updates on China Northwest University with Synapse

Overview

Tags

Skin and Musculoskeletal Diseases

Neoplasms

Other Diseases

Small molecule drug

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Immune System Diseases	2
Endocrinology and Metabolic Disease	1
Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	3
Chemical drugs	1

Top 5 Target	Count

AMPK(AMP activated protein kinase)	1
CysLT x β2-adrenergic receptor	1
KDM1A(Lysine-specific histone demethylase 1)	1
OAT1(solute carrier family 22 member 6)	1

Crust-mantle interaction occurs widely in orogenic belts, exerting a crucial role in understanding the petrogenesis of igneous rocks and the geodynamic processes of orogenic evolution.The East Kunlun Orogenic Belt (E-KOB), as a typical subduction-accretionary orogenic belt, underwent a prolonged subduction-accretionary evolutionary process from the Early Paleozoic to the Triassic, accompanied by multi-stage magmatic activity.A set of granodiorites with mafic microgranular enclaves (MMEs) outcropped in the Tuolahai of the Central Kunlun Belt is key to revealing the crust-mantle interaction correlated with subduction or collision in the E-KOB.In this study, petrol., mineral chem., whole-rock and isotopic geochem., and geochronol. investigations were conducted on the Tuolahai host granodiorites and MMEs to investigate their petrogenesis, magma source, and tectonic significance.The zircon U-Pb geochronol. suggests comparable crystallization ages of 247 ± 2 Ma and 246 ± 2 Ma for the host granodiorite and MMEs, resp.The host granodiorites are primarily composed of medium-to-coarse plagioclase, amphibole, quartz and biotite.Geochem., they exhibit calc-alk. and metaluminous, with enrichment in LILEs, and slight depletion in HFSEs, belonging to I-type granites.They display neg. ε_Nd(t) (-5.89 to -5.27) and ε_Hf(t) (-4.77 to -2.25), along with comparatively young two-stage Nd and Hf model ages (1.44-1.49 Ga and 1.41-1.57 Ga, resp.).These geochem. features suggest that the granodiorites originated predominantly from juvenile mafic lower crust, with contributions from deep mantle-derived materials, while experiencing minor upper crustal contamination during their ascent.Compared to the granodiorites, the MMEs exhibit a finer-grained texture composed of plagioclase, amphibole, biotite and quartz.Geochem., they display lower SiO₂ (50.12-54.13 wt%), higher MgO (4.13-5.29 wt%), ΣREE contents, similar rare earth element patterns, and ε_Nd(t) (-5.59 to -5.10), but distinctly different ε_Hf(t) (-7.68 to -0.14) values.Considering that the sharp contact, the plagioclase and amphibole xenocrysts in the MMEs are compositionally similar to those in the host rock, we propose that the MMEs represent products of magma mingling, with their sources primarily originating from mantle materials, indicating formation through the partial melting of an enriched lithospheric mantle.Comprehensive petrol., geochem. and mineral chem. indicate that the Tuolahai batholith is a product of crust-mantle interaction, where the upwelling of enriched lithospheric mantle led to partial melting of the mafic lower crust, forming hybrid magma and MMEs.Together with the regional geol. data, all the above lines of evidence allow us to propose that the Tuolahai granodiorites and the associated MMEs were formed through crust-mantle interaction during the northward subduction of the Paleo-Tethys Ocean.

06 Apr 2025·ICASSP 2025 - 2025 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)

Multi-Scale Conditional Generative Adversarial Networks for Wind Speed Data Imputation in Earthen Ruins Protection

Author: Li, Hang ; Ji, Shuo ; Wang, Hai ; Cao, Rui ; Zheng, Jie

01 Apr 2025·Journal of Environmental Chemical Engineering

Biodegradation of C18 n-alkane by biosurfactant-producing Pseudomonas aeruginosa TJM4 and its genomic analysis

Author: Rao, Qingyan ; Lu, Juncheng ; Ma, Yanling ; Liu, Shichuang ; Chen, Mengyao

Petroleum hydrocarbon pollution due to crude oil spillage has become a global concern, and the discovery of novel efficient oil hydrocarbon degrading strains remains a subject of attention.In the current study, strain TJM4 grew with medium-chain C18n-alkane and achieved 75.2% degradation efficiency after 7 days under the optimized conditions, including 38°C, pH 6.9, and 460 mg/L C18n-alkane.Strain TJM4 was identified as Pseudomonas aeruginosa, and the biosurfactant generated was defined to be rhamnolipid.To shed light on the genes connected with alkane metabolism, genome sequencing of strain TJM4 was performed.Genomic anal. revealed that it possesses a chromosome of 7044507 bp and 6443 protein-coding genes.Strain TJM4 harbors a multitude of genes responsible for alkane degradation, including five genes encoding putative alkane monooxygenases and other key enzymes.Meanwhile, RT-qPCR anal. showed that C18n-alkane could induce the expression of different alkane hydroxylase genes, with the expression of the alkMa gene notably elevated (5.4-fold).In addition, the mutant ΔalkMa was further constructed, and the degradation rate of C18n-alkane after 7 days by mutant ΔalkMa decreased to 57.1%.These results suggested that P. aeruginosa TJM4 might be a new potential bacterial resource for the biol. treatment of alkane pollution, and the genome anal. provided fundamental information for deeper exploration of the application potential of strain TJM4.

100 Deals associated with China Northwest University

Login to view more data

100 Translational Medicine associated with China Northwest University

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 11 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

3

Preclinical

Login to view more data

Current Projects

Drug(Targets)	Indications	Global Highest Phase

XC267 ( CysLT x β2-adrenergic receptor )	Asthma More	Preclinical
Ginsenoside Rh4 ( AMPK )	Breast Cancer More	Preclinical
Isoforsythiaside ( KDM1A )	Bacterial Infections More	Preclinical
CN119874791 ( OAT1 )	Hyperuricemia More	Discovery