Corona virus disease 2019(COVID-19)is located in Sanjiao and the lung collateral. The epidemic disease(wetness) enters the human body through the mouth and nose. The upper Jiao is attacked by epidemic diseases first, the internal stasis is endogenous, and obstructs the lung collateral. The epidemic pathogen spread quickly, which could reach the spleen and stomach of the middle Jiao, the liver and kidney of the lower Jiao, and accumulated in Sanjiao. Therefore, combined with the core idea of the Jiaoluo theory of "clearing static blood and turbidity in Sanjiao, tonifying the kidneys, and opening the Xuanluo", the author believes that the blocking of Sanjiao and the obstruction of the lung collateral are the main pathogenesis of COVID-19. The treatment method is mainly based on clearing static blood and turbidity in Sanjiao, detoxification and dredging collaterals, and removing dampness. If the pathogen invades the upper Jiao, it should be treated by dispersing the lung and detoxifying the toxin;then, the pathogen invades the middle Jiao, it should be treated by removing dampness and perversion;finally, the pathogen invades the lower Jiao, it should be treated by promoting diuresis, and the collaterals should be unblocked to remove static blood and turbidity. Qingfei Paidu Decoction aims at removing cold, heat, dampness, toxins, deficiency and other pathogenic qi with multiple methods. It is both pungent-warm and pungent-cool, sweet and fragrant, focusing on clearing rather than blocking, aiming to provide a way out for pathogenic qi. This coincides with the idea that Jiao Luo theory returns to the essence of yin and yang, emphasizing the rise and fall of the qi movement, taking blocking for use, taking blocking for supplement and taking blocking for smooth.