Guilin Dahua Pharmaceutical Co. Ltd.

Main research purpose: According to the relevant provisions of bioequivalence test, the certified tacrolimus capsules (trade name: Prograf, specification: 1mg) of Astellas Pharma Co.Limited were selected as the reference preparation, and the test preparation tacrolimus capsules (specification: 1mg) produced by Hunan Kelun Pharmaceutical Co., Ltd. and provided by Guangxi Kelun Pharmaceutical Co., Ltd. were subjected to fasting human bioequivalence test to compare whether the absorption rate and degree of the drug in the test preparation were within the acceptable range with the reference preparation, and to compare the bioequivalence of the two preparations under fasting conditions. Secondary research purpose: To observe the safety of oral administration of the test preparation tacrolimus capsules (specification: 1mg) and the reference preparation tacrolimus capsules (trade name: Prograf, specification: 1mg) by healthy subjects.

Main research purpose: According to the relevant provisions of bioequivalence test, the tacrolimus capsules (trade name: Prograf, specification: 1mg) certified by Astellas Pharma Co.Limited were selected as the reference preparation, and the test preparation tacrolimus capsules (specification: 1mg) produced by Hunan Kelun Pharmaceutical Co., Ltd. and provided by Guangxi Kelun Pharmaceutical Co., Ltd. were subjected to human bioequivalence test after meal administration, to compare whether the absorption rate and degree of the drug in the test preparation were within the acceptable range with the reference preparation, and to compare the bioequivalence of the two preparations under the condition of postprandial administration. Secondary research purpose: To observe the safety of oral administration of the test preparation tacrolimus capsules (specification: 1mg) and the reference preparation tacrolimus capsules (trade name: Prograf, specification: 1mg) by healthy subjects.

Main research purpose: According to the relevant provisions of bioequivalence test, the ilaprazole enteric-coated tablets (trade name: Yilian, specification: 5mg) of which Livzon Pharmaceutical Factory of Livzon Group is the licensee was selected as the reference preparation, and the test preparation ilaprazole enteric-coated tablets (specification: 5mg) produced and provided by Sichuan Kelun Pharmaceutical Co., Ltd. were subjected to human bioequivalence test on fasting and postprandial administration, to compare whether the absorption rate and degree of the drug in the test preparation were within the acceptable range with the reference preparation, and to evaluate the bioequivalence of the two preparations under fasting and postprandial administration conditions. Secondary research purpose: To observe the safety of oral administration of the test preparation ilaprazole enteric-coated tablets (specification: 5mg) and the reference preparation ilaprazole enteric-coated tablets (trade name: Yilian, specification: 5mg) to healthy subjects.