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Small molecule drug	1
Antibody fusion proteins	1

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ADMR(Adrenomedullin receptor)	1

Author: Misawa, Naoaki ; Singhla, Tawatchai ; Tiwananthagorn, Saruda ; Nambooppha, Boondarika ; Hayashi, Naoki ; Yoshida, Ayako ; Nonaka, Nariaki ; Sangarun, Kanyatip ; Kunkaew, Chakorn ; Chotiphutthikul, Chanakan ; Rompo, Thanakorn ; Suphakarn, Saravalee ; Sripakdee, Duanghatai ; Nakao, Ryo ; Matsui, Yuto ; Chintapitaksakul, Lerdchai ; Teo, Ernest ; Limwibulpong, Kanthanis ; Suwongsaksri, Napatsorn ; Wanganurakkul, Saruda ; Irie, Takao

Gastrointestinal parasites, particularly strongyle nematodes, pose a significant threat to the health of ruminants. Due to the technical limitations of microscopic and conventional PCR-based methods, the strongyle parasite fauna has not been well studied even in common livestock animals. The present study aimed to investigate the prevalence and diversity of strongyle nematodes in three ruminant species in northern Thailand using a nemabiome approach. Fecal samples were collected from buffaloes, cattle, and goats that were raised for meat and for dairy in four provinces in northern Thailand. Strongyle infections were determined using egg flotation and McMaster techniques followed by DNA metabarcoding for species identification. The results showed high prevalence of strongyles especially in goats raised for meat (88 %), and in goats raised for dairy (72 %). Significantly more goats and cattle raised for meat were strongyle egg-positive compared to their dairy counterparts. Notably, deworming frequency was not significantly associated with strongyle egg-positivity in all ruminant groups apart from dairy goats. Nemabiome analysis identified 11 strongyle species across seven genera. Among the ruminant hosts, beef cattle exhibited the highest strongyle richness. Additionally, the dominance of specific strongyle species influenced the differences observed in diversity indices. This research is the first to apply the nemabiome approach to assess strongyle nematode diversity in northern Thailand, providing valuable insights into nematode community compositions. These findings emphasize the importance of molecular techniques for parasite monitoring and the development of targeted control strategies.

01 Sep 2025·Journal of Photochemistry and Photobiology A: Chemistry

Light-driven mechanical motion of a two-dimensional network of polyfluorinated surfactants having azobenzene moiety sandwiched by niobate nanosheets: Effect of pH of intercalation solution

Author: Shiragami, Tsutomu ; Hassan, Syed Zahid ; Koganemaru, Kazuki ; Nabetani, Yu ; Tachibana, Hiroshi ; Inoue, Haruo

A hybrid composed of polyfluoroalkyl azobenzene derivative (C3F-Azo-C6H) and layered niobate nanosheet can undergo interlayer distance change and nanosheet sliding motion upon photo-irradiations.However, such morphol. changes are not yet sufficiently controlled, exhibiting somewhat fluctuating results.It is necessary to clarify what kind of intercalation environment promotes the high-order architecture formation suitable for the more efficient photo-induced morphol. change.In this study, we have focused on the pH conditions of intercalation solution and analyzed the nanostructure and morphol. change of the hybrid fabricated under the basic (pH = 11.0) and the acidic (pH = 2.4) conditions.Intercalating C3F-Azo-C6Hs into the nanosheets under the basic condition afforded a larger interlayer distance as compared with that under the acidic condition.Furthermore, the more substantial interlayer distance change (expansion ratio: 21%) and the nanosheet sliding (sliding distance: ≈ 200 nm) were successfully induced upon UV-vis photo-irradiations of the hybrid fabricated under the basic conditions, while the hybrid fabricated under the acidic conditions exhibited the smaller changes (interlayer expansion ratio: 0.8% with unstable/negligible nanosheet sliding).Under the basic conditions, the nanostructure of the C3F-Azo-C6Hs bilayer having non-interdigitation of the terminal alkyl chain of the two-monolayers faced each other in the bilayer caused the substantial morphol. changes such as interlayer distance change and nanosheet sliding, whereas the deeply interdigitated terminal alkyl chains in the hybrid fabricated under the acidic conditions caused only a little/negligible morphol. change.Factors controlling the drastic changes of the nanostructure derived from the different fabrication conditions have been discussed.

01 Sep 2025·Journal of Behavior Therapy and Experimental Psychiatry

Functional assessment of hikikomori behaviors: Functional types and psycho-behavioral factors

Article

Author: Takeda, Tomoya ; Nonaka, Shunsuke ; Sakai, Motohiro

Hikikomori is a condition of prolonged social withdrawal (at least six months) characterized by not working or attending school, not socializing outside one's home, and staying at home on most days except for solitary outings. Currently, there are no adequate tools for the assessment of individual differences in hikikomori functions. This study involved the development of the Hikikomori Functional Assessment Scale (HFAS), which quantitatively assesses the perceived functions of hikikomori. Three data samples were collected at different time periods and included 490 participants with hikikomori and 251 without hikikomori. An item pool was analyzed resulting in 17 items and three factors: intrapersonal-positive (pursuing activities and self-stimulatory behaviors), intrapersonal-negative (alleviating discomfort), and social-negative (avoiding social interactions) reinforcement. The HFAS showed good internal consistency reliability, moderate-to-good test-retest reliability, acceptable construct validity, and good criterion-related validity. Furthermore, social-negative reinforcement correlated positively with measures of depressive symptoms and subjective social functioning impairment and negatively with adaptive behavior and quality of life. Intrapersonal-negative reinforcement was weakly correlated with most of the related scales, and intrapersonal-positive reinforcement showed no significant correlations. Future studies are needed to confirm the consistency of functional assessment results with those of the HFAS, using behavioral observations by researchers and clinicians, and follow the changes in hikikomori functioning longitudinally.

100 Deals associated with University of Miyazaki

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100 Translational Medicine associated with University of Miyazaki

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Pipeline

Pipeline Snapshot as of 10 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Pegylated adrenomedullin	Colitis, Ulcerative More	Phase 2
Adrenomedullin(University of Miyazaki) ( ADMR )	Colitis, Ulcerative More	Phase 2
JNASE-7001 ( GLP-1R )	Diabetes Mellitus, Type 2 More	Pending
R723 ( JAK2 )	Neoplasms More	Pending