Shandong Lukang Pharmaceutical Group Saite Co., Ltd.

Primary objective: To investigate the relative bioavailability of a single oral dose of dapagliflozin tablets 10 mg (test formulation) manufactured by Shandong Lukang Pharmaceutical Group Co., Ltd., and the original dapagliflozin tablets 10 mg (FORXIGA®/Andatang®, reference formulation) manufactured by AstraZeneca (AstraZeneca AB), in healthy subjects under fasting conditions, and to evaluate the bioequivalence between the test and reference formulations. Secondary objective: To observe the safety and tolerability of the test and reference formulations in healthy Chinese subjects by monitoring changes in adverse event rates, laboratory test results, vital signs, and physical examination findings.

Primary objective: To investigate the pharmacokinetic parameters and relative bioavailability of nifedipine controlled-release tablets (30 mg) developed by Shandong Lukang Pharmaceutical Group Co., Ltd. (T) as the test formulation (T), and nifedipine controlled-release tablets (30 mg, trade name: Adalat®) manufactured and licensed by Bayer AG as the reference formulation (R), under fasting and postprandial administration, and to evaluate whether the two formulations are bioequivalent. Secondary objective: To evaluate the safety of the test and reference formulations (Adalat®) of nifedipine controlled-release tablets in healthy participants.

Main objective: To study the relative bioavailability of a single oral dose of 0.1 g of norfloxacin capsules (test preparation, specification: 0.1 g) produced by Shandong Lukang Pharmaceutical Group Saite Co., Ltd. and 0.1 g of norfloxacin tablets (BACCIDAL®, reference preparation, specification: 0.1 g) produced by Kyorin Pharmaceutical Co., Ltd. in healthy subjects under fasting state, and to evaluate the bioequivalence of the two preparations. Secondary objective: To observe the safety and tolerability of the test and reference preparations in healthy Chinese subjects by observing the changes in the incidence of adverse events, laboratory test results, vital signs, and physical examinations.