Bardet-Biedl Syndrome (BBS) is an uncommon genetic disorder that affects multiple organs. and presents with a variety of characteristics. It is caused by a dysfunction in the cilia. We present a case of bradet-biedl syndrome presenting with intellectual disabilities, post-axial polydactyly, gingival hyperplasia, and a significant family history of scleroderma. The diagnosis was determined based on clinical physical examination findings. The patient is undergoing treatment with Thyroxine. Although medical staff are incapable of treatment, systems support adjust the overall well-being and quality of life for individuals with Bardet-Biedl syndrome and their families.

Start Date12 Oct 2024

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Al Baath University

100 Clinical Results associated with Al Baath University

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Literatures (Medical) associated with Al Baath University

01 Apr 2025·Annals of Medicine & Surgery

A 37-year-old female with carotid body paragangliomas and metastases in the lung: a rare case report from Syria

Article

Author: Tannous, Elias ; Khattab, Raneem ; Othman, Abdulrahman Ahmad ; Alfandi, Abdullah ; Alhomsi, Khaled ; Alajrd, Abd Alrhman ; Sleiay, Bilal ; Yabroudi, Moath ; Sleiay, Mouhammed ; Khattab, Khalid ; Alhomsi, Malaz ; Alzuhili, Mulhm ; Sandouk, Hashem ; Almohammad, Taha

Introduction:A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax, and abdomen). It is a benign tumor, but in rare cases, it can metastasize to other parts of the body. In less than 30%, this tumor secretes catecholamines. Norepinephrine is dominant in extra-adrenal asymptomatic cases, or its symptoms include headaches, hypertension, or sympathetic paraganglia. The tumor may cause palpitations, excessive sweating, and anxiety. Usually, laboratory tests such as catecholamine tests and imaging tests are used to diagnose it .Surgery is the most common treatment, but there are other treatment options, including radiation therapy, chemotherapy, or targeted therapy.Case presentation:We present a 37-year-old female with parietal chest pain, exertional dyspnea, palpitations, and left neck swelling, found to have metastatic paraganglioma diagnosed via biopsy. The patient underwent surgery to remove the tumor, resulting in significant symptom improvement without complications.Clinical discussion:Paragangliomas (PGLs) are neuroendocrine tumors found in ganglia, with head and neck PGL (HNPGL) making up 65–70% of PGL cases. Most HNPGLs are benign, but 6–19% can metastasize, complicating diagnosis and surgical removal due to vascular challenges and potential complications like Horner syndrome and CN damage.Conclusion:Paragangliomas can cause varied symptoms, sometimes mimicking other conditions. Rarely, carotid body tumors may metastasize, potentially explaining atypical symptoms alongside classic ones.

01 Apr 2025·Clinical Rheumatology

Electroacupuncture delays the progression of juvenile collagen-induced arthritis via regulation NLRP3/ NF-κB signaling pathway -mediated pyroptosis and its influence on autophagy

Article

Author: Khadour, Younes A ; Xu, Tao ; Khadour, Fater A

BACKGROUNDJuvenile idiopathic arthritis (JIA) can lead to synovial inflammation. JIA is a chronic autoimmune inflammatory condition that primarily affects children. It is recognized as the most prevalent form of arthritis in the pediatric population and is associated with significant impairment and disability. Electroacupuncture (EA) effectively treats various synovium-related conditions, including symptoms of synovial inflammation, in both human and animal models. However, the specific mechanism by which EA protects against JIA remains unclear. Therefore, we conducted a comprehensive study to investigate the protective mechanisms of EA in a rat model. We aimed to examine the impact of EA on pathological changes in synovial tissue of juvenile collagen-induced arthritis (CIA) rats.METHODSThe CIA model was established using Sprague‒Dawley (SD) rats aged 2-3 weeks. In this study, we investigated the potential role of EA on JIA by regulating the NLRP3-NF-κB axis in juvenile CIA rats and its influence on autophagy. To verify the effect of EA on juvenile CIA, the expression of NLRP3 was overexpressed by an adeno-associated virus injected into the knee joint of the CIA rats.RESULTSIn this study, we observed that NLRP3 plays an important role in developing juvenile CIA and that NLRP3 overexpression exacerbates inflammation and increases synovium inflammation. We also demonstrated that the expression of NLRP3 was increased in synovial tissue, and NLRP3 could upregulate the NF-κB signal pathway and influence inflammation. Moreover, we also found increases in the expression of NLRP3 by impairing autophagy capacity and activation of the pyroptosis pathway in the synovium of the juvenile CIA rats.CONCLUSIONMoreover, we also discovered that EA decreased the expression of NLRP3 by restoring the impaired autophagy capacity and inhibiting the NLRP3-NF-κB axis, thereby delaying the progression of juvenile CIA. These results showed that EA is effective in inhibiting inflammation and synovial degeneration and alleviating the progression of juvenile CIA. As a result, our results provide new insight into the mechanism by which EA delays the development of juvenile CIA, offering a novel therapeutic regimen for JIA. This trial was registered with ClinicalTrials.gov, number NCT10203935. Registered October 07, 2023. Key Points • NLRP3 plays a critical role in juvenile collagen-induced arthritis (CIA), with its overexpression linked to increased inflammation in synovial tissue. • Electroacupuncture (EA) reduces NLRP3 expression and inhibits the NLRP3-NF-κB axis, mitigating inflammatory responses and delaying juvenile CIA progression. • EA restores impaired autophagy in juvenile CIA rats, promoting cellular health and inflammation management. • EA alleviates synovial degeneration, improving joint health and function in juvenile CIA models.

01 Apr 2025·Clinical Rheumatology

Electroacupuncture for juvenile idiopathic arthritis: clinical efficacy and its role in modulating pyroptosis and autophagy pathways

Article

Author: Khadour, Younes A ; Xu, Tao ; Khadour, Fater A

BACKGROUNDJuvenile idiopathic arthritis (JIA) is a common chronic inflammatory disorder in children, leading to significant physical and psychosocial challenges. Current treatments often fall short, prompting interest in complementary therapies. This study aims to evaluate the effectiveness of electroacupuncture (EA) on clinical outcomes in children with JIA, focusing on its impact on the pyroptosis pathway and autophagy function.METHODSA randomized controlled clinical trial was conducted from 7 November 2023 to 12 January 2025. A total of 106 participants were recruited and randomly assigned to receive EA or sham acupuncture (SA) for 8 weeks. Clinical assessments, including functional ability, pain scores, and quality of life, were measured at baseline, week 4, week 8, month 3, and month 6. Serum levels of pyroptosis-related proteins and autophagy markers were analyzed to elucidate the underlying mechanisms.RESULTSThe EA group showed significant improvements in functional ability and pain scores compared to the SA group at both week 4 and week 8. Notable reductions in serum levels of pyroptosis markers (caspase-1, GSDMD, NLRP3) and pro-inflammatory cytokines (IL-1β, IL-18) were observed in the EA group. Additionally, autophagy markers (LC3, Becline1) significantly decreased after EA treatment, suggesting enhanced autophagic activity.CONCLUSIONThis study demonstrates that electroacupuncture is a safe and effective adjunctive treatment for improving function and reducing pain in children with JIA. The observed biological changes indicate potential anti-inflammatory effects, supporting EA's role in comprehensive JIA management. Future research should explore long-term outcomes and mechanisms for these findings further. Key Points • The study demonstrates that electroacupuncture (EA) significantly improves functional ability and pain scores in children with juvenile idiopathic arthritis (JIA) compared to sham acupuncture. • EA treatment led to notable reductions in serum levels of pyroptosis-related proteins and pro-inflammatory cytokines, indicating its potential role in modulating inflammatory pathways. • The research observed significant changes in autophagy markers post-EA treatment, suggesting that EA may enhance autophagic function in children with JIA. • EA is presented as a safe adjunctive therapy for JIA management, with implications for further research into its long-term effects and underlying mechanisms.

News (Medical) associated with Al Baath University

15 Nov 2022

·www.prnewswire.com

Hani Kador, MD, FACC, is recognized by Continental Who's Who

GROSSE POINTE PARK, Mich., Nov. 15, 2022 /PRNewswire/ -- Hani Kador, MD, FACC, is being recognized by Continental Who's Who as a Trusted Healthcare Professional in the Medical field and in acknowledgment of his outstanding work at Eastside Cardiovascular Medicine. Continue Reading Hani Kador With 14 years of experience in medicine, Dr. Kador is a board-certified, fellowship-trained interventional cardiologist affiliated with Eastside Cardiovascular Medicine in Roseville, MI. He can also be found on staff at Beaumont Hospital Grosse Pointe. As an interventional cardiologist, the doctor sees patients who typically are in life and death situations. He treats patients for cardiovascular disease, peripheral artery disease, arrhythmia, heart attacks, pulmonary embolisms, and blockages. He is very responsive to his patient's needs, forming personal relationships with them. Cardiology is a branch of medicine that deals with the disorders of the heart and some parts of the circulatory system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart disease, and electrophysiology. Cardiologists are doctors who diagnose, assess, and treat patients with diseases and defects of the heart and blood vessels (the cardiovascular system). A native of Syria, Dr. Kador graduated in 2005 with his Medical Doctor degree (M.D.) from Al-Baath University, where he ranked as one of the top three graduates in his class. Upon relocating to the United States, he completed his residency in internal medicine and was Chief Resident at the Ascension St. John's Medical Center. in 2012. Wanting to further his education, he completed two consecutive fellowships in cardiovascular disease and interventional cardiology at the same academic institution in 2016 and 2017, respectively. Recognized as a member of the American College of Physicians (ACP) and a Fellow of the American College of Cardiology (FACC), the doctor is board certified in internal medicine, general cardiology, interventional cardiology, echocardiography, and nuclear imaging. On a personal note, Dr. Kador is fluent in English and Arabic. Dr. Kador dedicates this recognition to the loving memory of his father, Faiez Kador. For more information, visit . SOURCE Continental Who's Who

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