Comparison of the Outcomes of Three Port and Four Port Laparoscopic Cholecystectomy in Patients Presenting to Tertiary Care Hospital: A Randomized Controlled Trial

Laparoscopic cholecystectomy is done traditionally with four ports. It has been observed that the same could be achieved using three ports. In this study we will study the outcomes of laparoscopic cholecystectomy done with both techniques.

Start Date01 Jul 2025

Sponsor / Collaborator

Khyber Medical College

ACTRN12624000572561

/ CompletedNot Applicable

Efficacy and safety of 27G vs 25G Quincke spinal needle on post Dural puncture headache after spinal anesthesia in patients undergoing elective caesarean section.

Start Date13 May 2024

Sponsor / Collaborator

Khyber Medical College

ChiCTR2300074509

/ SuspendedPhase 1

Comparison of Dentoskeletal and Soft Tissue Changes among Growing Class II Patients undergoing Conventional Twin Block Therapy versus Esthetic Twin Block Therapy: Two-Arm Randomized Controlled Trial

Start Date15 Aug 2023

Sponsor / Collaborator

Khyber Medical College

100 Clinical Results associated with Khyber Medical College

0 Patents (Medical) associated with Khyber Medical College

844

Literatures (Medical) associated with Khyber Medical College

01 Dec 2025·Journal of Gastrointestinal Cancer

Comparing Operative Outcomes and Resection Quality in Robotic vs Open Pancreaticoduodenectomy: A Meta-analysis of 54,000 Patients

Review

Author: Khan, Haseeb Javed ; Butt, Hassan Tariq ; Kamran, Mohammad Saboor ; Durrani, Rafia ; Shakoor, Pakeeza ; Dilawar, Esha ; Jeswani, Hema Kumari ; Mughees, Ibrahim ; Waseem, Muhammad Hassan ; Ahad, Abdul ; Qazi, Shurjeel Uddin ; Ali, Muhammad ; Kazmi, Syeda Aliza ; Abideen, Zain Ul ; Tariq, Muhammad Arslan

BACKGROUNDHigh morbidity and mortality make pancreaticoduodenectomy (PD) one of the most complicated surgical procedures. This meta-analysis aimed to compare the outcomes of robotic pancreaticoduodenectomy (RPD) versus open pancreaticoduodenectomy (OPD).METHODA comprehensive literature search of PubMed, Cochrane Central, and Google Scholar was conducted from inception to November 2024. Studies comparing RPD and OPD in adults aged ≥ 18 years were included. Data for the outcomes of interest were extracted.RESULTSForty-one studies with a total of 54,287 patients were pooled. RPD is significantly superior to OPD in terms of overall postoperative complications (RR = 0.91, 95% CI: [0.86-0.97]; p = 0.001), wound infections (RR = 0.63, 95% CI: [0.49-0.81], p = 0.0004), estimated blood loss (WMD = -171.99 ml, 95% CI: [ -217.76 to -126.22], p < 0.01) and hospitalization duration (WMD = -1.33 days, 95% CI: [ -1.84 to -0.82], p < 0.01) with a longer operating time (WMD = 73.22 min, 95% CI: [56.20 to 90.23], p < 0.01).CONCLUSIONIn conclusion, RPD shows a lower risk of wound infections and overall postoperative morbidity compared to OPD. It has lower estimated blood loss, shorter hospitalization duration, and a longer operating time. The two approaches were comparable in terms of resection quality. More high-quality RCTs are required to draw definite conclusions.

01 Jul 2025·International Journal of Cardiology

Critical appraisal of “Risk and Predictors of First-Time Infective endocarditis in adult patients with congenital heart disease—A Nationwide, register-based study”

Letter

Author: Iqbal, Javed ; Alam, Umama ; Bacha, Zaryab ; Henna, Fathimathul

01 Jun 2025·IJC Heart & Vasculature

Outcomes of transcatheter vs surgical aortic valve replacement in pre-existing chronic liver disease patients: A meta-analysis of observational studies

Review

Author: Ali, Muhammad Abdullah ; Ali, Aizaz ; Jalal, Urbe ; Afridi, Abdullah ; Khan, Malik W Z ; Collins, Peter ; Khan, Ayesha ; Khattak, Fazia ; Ahmed, Raheel ; Shabbar Banatwala, Umme Salma ; Moeez, Abdul ; Azeem, Touba ; Alam, Umama ; Khattak, Asad Iqbal

Aortic valve stenosis in patients with chronic liver diseases, particularly liver cirrhosis and End-Stage Liver Disease, poses significant management challenges due to the interplay between cardiovascular and hepatic dysfunction. This systematic review and meta-analysis compared the safety and efficacy of Transcatheter Aortic Valve Replacement (TAVR) and Surgical Aortic Valve Replacement in this high-risk population. An extensive search of PubMed, Embase, and Web of Science (inception to January 5, 2025) identified 11 retrospective studies comprising 19,097 patients. Risk ratios for dichotomous outcomes and mean differences (MD) for continuous outcomes, each with 95% confidence intervals, were calculated using random-effects models. The analysis revealed that TAVR significantly reduced hospital mortality (RR 0.36, 95 % CI: 0.30-0.42; I² = 7.6 %), acute kidney injury (RR 0.51, 95 % CI: 0.33-0.78; I² = 57.2 %), bleeding (RR 0.33, 95 % CI: 0.28-0.39; I² = 0.0 %), stroke (RR 0.35, 95 % CI: 0.23-0.51; I² = 6.1 %), and blood transfusion (RR 0.48, 95 % CI: 0.40-0.57; I² = 7.6 %). TAVR was also associated with shorter hospital stays (MD -6.77 days, 95 % CI: -9.17 to -4.38; I² = 97.5 %). No significant differences were observed in vascular complications requiring surgery or hospital charges and post-operative infections. These findings suggest TAVR offers significant advantages over SAVR in reducing complications such as mortality, acute kidney injury, and bleeding in patients with liver disease. However, further randomized trials are necessary to confirm long-term outcomes and establish optimal treatment strategies for this high-risk population.

100 Deals associated with Khyber Medical College

100 Translational Medicine associated with Khyber Medical College

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