Study on the clinical efficacy of auricular vagus nerve stimulation and synchronous head acupuncture in the treatment of swallowing dysfunction after stroke

Start Date30 Apr 2025

Sponsor / Collaborator

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

ITMCTR2025000599

/ SuspendedNot Applicable

Effect of acupuncture on rapid pain relief recovery of motor function and infrared thermographic changes in athletic acute external ankle sprains

Start Date31 Mar 2025

Sponsor / Collaborator

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

ITMCTR2025000520

/ SuspendedNot Applicable

A Randomized Open-label Dose-finding Parallel-group Controlled Clinical Trial with a Positive Drug to Evaluate the Efficacy and Safety of Jingfang Mixture in the Treatment of Chronic Urticaria (Syndrome of Wind-cold)

Start Date17 Mar 2025

Sponsor / Collaborator

The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

100 Clinical Results associated with The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

0 Patents (Medical) associated with The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Literatures (Medical) associated with The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

01 May 2025·Genes & Diseases

Research progress on the use of traditional Chinese medicine to treat diseases by regulating ferroptosis

Review

Author: Chen, Changjing ; Zheng, Sanxia ; Yang, Xianzhen ; Zhang, Denglu ; Xu, Xiangdong ; Qi, Lei ; Liu, Shuai

Ferroptosis is an emerging form of programmed cell death triggered by iron-dependent lipid peroxidation. It is distinguished from other forms of cell death by its unique morphological changes and characteristic fine-tuned regulatory gene network. Since its pivotal involvement in the pathogenesis and therapeutic interventions of various diseases, such as malignant tumors, cardiovascular and cerebrovascular diseases, and traumatic disorders, has been well-established, ferroptosis has garnered significant attention in contemporary physiological and pathological research. For the advantage of alleviating the clinical symptoms and improving life quality, traditional Chinese medicine (TCM) holds a significant position in the treatment of these ailments. Moreover, increasing studies revealed that TCM compounds and monomers showed evident therapeutic efficacy by regulating ferroptosis via signaling pathways that tightly regulate redox reactions, iron ion homeostasis, lipid peroxidation, and glutathione metabolism. In this paper, we summarized the current knowledge of TCM compounds and monomers in regulating ferroptosis, aiming to provide a comprehensive review of disease management by TCM decoction, Chinese patent medicine, and natural products deriving from TCM through ferroptosis modulation. The formulation composition, chemical structure, and possible targets or mechanisms presented here offer valuable insights into the advancement of TCM exploration.

27 Mar 2025·Current Molecular Medicine

Bone Marrow Mesenchymal Stem Cell Senescence in the Development of Osteoporosis: Mechanisms, Interventions, and Future Directions

Article

Author: Du, Gang ; Li, Chengen ; Zhang, Jiuchao ; Guo, Cunliang ; Yang, Zhenguo ; Liu, Kun ; Li, Bo

Abstract:Osteoporosis, a significant age-related disease, is marked by diminished bone density and an elevated risk of fractures, representing a considerable global health challenge. Bone marrow mesenchymal stem cells (BMSCs) are essential in maintaining bone integrity through their differentiation into osteoblasts, which are crucial for bone formation. Nevertheless, the aging of BMSCs diminishes their regenerative abilities and intensifies inflammation, thereby playing a critical role in osteoporosis pathogenesis. This review explores the intricate mechanisms of BMSC senescence and its influence on osteoporosis, detailing cellular and molecular markers, such as oxidative stress, the senescence-associated secretory phenotype (SASP), and pivotal signaling pathways, including P53, PI3K/mTOR, and autophagy. We assess current interventions aimed at reducing BMSC senescence, with an emphasis on pharmacological methods like melatonin and antioxidants, alongside nonpharmacological strategies, such as exercise and dietary supplementation with omega-3 fatty acids. Furthermore, the challenges and limitations of translating these strategies into clinical applications are addressed, highlighting the necessity for personalized medicine to accommodate treatment outcome variability. Future research directions should focus on emerging therapeutic targets and novel interventions, such as gene editing technologies and advanced tissue engineering techniques. By integrating these strategies, this review endeavors to enhance the understanding and treatment of osteoporosis, emphasizing the critical need to target BMSC senescence to develop effective therapies.

05 Mar 2025·Europace

Aggressive ablation vs. regular ablation for persistent atrial fibrillation: a multicentre real-world cohort study

Article

Author: Ji, Anjing ; Zhang, Yu ; Zheng, Qidong ; Xu, Kai ; Liu, Xu ; Shi, Yangbin ; Zhang, Menghe ; Hou, Xumin ; Han, Bing ; Li, Kaige ; Wu, Shaohui ; Qin, Mu ; Wang, Yanzhe ; Ye, Ping ; Jiang, Weifeng ; Wang, Xinhua

AbstractAimsCurrent guidelines for the optimal ablation strategy for persistent atrial fibrillation (PerAF) remain unclear. While our previous RCT confirmed the favourable prognosis of aggressive ablation, real-world evidence is still lacking.Methods and resultsAmong 4833 PerAF patients undergoing catheter ablation at 10 centres, two groups were defined: regular ablation (PVI-only or PVI plus anatomical ablation) and aggressive ablation (anatomical plus electrogram-guided ablation), with 1560 patients each after propensity score (PS) matching. The primary endpoint was 12-month AF/atrial tachycardia (AT) recurrence-free survival off anti-arrhythmic drugs after a single procedure. Additional PS matching was performed within the regular group between PVI-only and anatomical ablation (n = 455 each). Furthermore, anatomical ablation from the regular group was independently matched with aggressive ablation (n = 1362 each). At 12 months, the aggressive group showed superior AF/AT-free survival (66.2% vs. 59.3%, P < 0.001; HR 0.745), similar AT recurrence (12.0% vs. 11.3%, P = 0.539), and significantly higher procedural AF termination (67.0% vs. 21.0%, P < 0.001) than regular group. Moreover, patients with AF termination had improved AF/AT-free survival (72.3% vs. 55.2%, P < 0.001). Safety endpoints did not differ significantly between the two groups. Both the ablation outcomes and AF termination rate showed increasing trends with the extent of ablation aggressiveness but declined with extremely aggressive ablation. After additional PS matching, within the regular group, no statistical differences were observed though AF/AT-free survival in the anatomical group was slightly higher than the PVI-only group (60.7% vs. 55.6%, P = 0.122); while aggressive ablation showed improved AF/AT-free survival compared to anatomical ablation alone from regular group (67.5% vs. 59.9%, P < 0.001).ConclusionAggressive ablation achieved more favourable outcomes than regular ablation, and moderately aggressive ablation may be associated with better clinical outcomes. AF termination is a reliable ablation endpoint.

100 Deals associated with The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

100 Translational Medicine associated with The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine

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