University of Primorska

The randomized, open-label, two period crossover single-dose bioavailability study with two coenzyme Q10 products

The purpose of this study will be to compare the effects of instrument assisted soft tissue mobilization at different muscle lengths on pain pressure thresholds and measures of flexibility.

The goal of this clinical trial is to assess the effectiveness of dietary supplement combined with exercise in managing knee osteoarthritis (KOA). The main questions it aims to answer are:
* Is adding a dietary supplement to exercise additionally effective in managing KOA?
* Is adding exercise to the dietary supplement additionally effective in managing KOA?
Participants will be given in three groups:
1. Real dietary supplement alone
2. Real dietary supplement with exercise
3. Placebo dietary supplement with exercise
Investigators will compare groups 1 and 2, or 2 and 3, to answer the research questions.
The hypothesis is that participants who receive the dietary supplement along with exercise will experience greater reduction in pain level, improved physical function, and enhanced quality of life compared to those who receive a placebo combined with exercise or dietary supplement alone.