Delving into the Latest Updates on Shenyang Yaoda Pharmaceutical Co. Ltd. with Synapse

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Urogenital Diseases

Small molecule drug

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The flurbiprofen-loaded nanostructured lipid carriers gel was prepared and the phys. properties such as the rheol., adhesiveness and gel strength were studied.The rheol. properties and dynamic rheol. spedrometer were studied on coaxial cylinder rheometer.The adhesiveness and the gel strength were measured by texture analyzer.The study of rheol. indicated that pseudoplastic flows with thixotropy were obtained for all NLC-gels after storage at three different temperatures, and high temperature was not conducive to maintain its internal structure of gel.Texture anal. showed that the gel storage under low temperature could keep higher adhesiveness and gel strength.Phys. properties such as the rheol., adhesiveness and gel strength and phys. stability of FP-NLC-Gel can be affected by storage temperature

Shenyang Yaoke Daxue Xuebao

Application of central composite design-response surface methodology to formulation of flurbiprofen-loaded nanostructured lipid carriers gel

Author: Yin, Ran ; Han, Fei ; Li, Sanming ; Sun, Xiaojiao ; Zhao, Sha ; Wei, Min

Flurbiprofen-loaded nanostructured lipid carriers gel was prepared and optimized using central composite design-response surface methodol. in order to obtain a formulation with optimized properties.Effects of formulation variables (amount of Carbopol 940, amount of azone and amount of propylene glycol) on a number of response variables were systemically investigated.The response variables were cumulative amount of percutaneous penetration.A desirability function that combines the response variable was constructed.A second-order polynomial equation was fitted to the data, and the resulting equation was used to predict the responses in the optimal region.The response variable was found to be highly dependent on the formulation variables.The optimum cumulative amount of percutaneous penetration of the flurbiprofen-loaded nanostructured lipid carriers gel can be obtained at 0.15 g of Carbopol 940, 0.70 g of azone and 1.50 g of propylene glycol.The exptl. values of the response variables highly agreed with the predict values.Central composite design-response surface methodol. is successfully used to optimize the preparation of flurbiprofen-loaded nanostructured lipid carriers gel.Overall desirability can be used to represent the most desirable variables in exptl. design.

Shenyang Yaoke Daxue Xuebao

Application of central composite design-response surface methodology to formulation of flurbiprofen-loaded nanostructured lipid carriers

Author: Yin, Ran ; Han, Fei ; Ren, Ping ; Zhan, Xiaoliang ; Li, Sanming ; Nan, Ning

An optimized formulation of flurbiprofen-loaded nanostructured lipid carriers was obtained by using central composite design-response surface methodol.The effects of formulation variables (amount of flurbiprofen, amount of lecithin, amount of Poloxamer 188 and Tween-80, amount of sodium deoxycholate) on a number of response variables were systemically investigated.The response variables were particle size, zeta potential, entrapment efficiency and drug loaded.A desirability function that combined these four response variables was constructed.A second-order polynomial equation was fitted to the data, and the resulting equation was used to predict the responses in the optimal region.All the investigated response variables were found to be highly dependent on the formulation variables.It was found that the optimum overall desirability of the flurbiprofen-loaded nanostructured lipid carriers could be obtained at 0.222 g of flurbiprofen, 0.300 g of lecithin, 2.000 g of poloxamer 188 and Tween-80, and at 0.100 g of sodium deoxycholate.The exptl. values of the response variables highly agreed with the predict values.Central composite design-response surface methodol. was successfully used to optimize the preparation of flurbiprofen-loaded nanostructured lipid carriers.Overall desirability could be used to represent the most desirable variables in exptl. design.

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Pipeline

Pipeline Snapshot as of 15 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

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