Delving into the Latest Updates on Antibody Solutions, Inc. with Synapse

Overview

Basic Info

Introduction

Antibody Solutions is a company that specializes in providing customized antibody-based solutions for research, diagnostics, and therapeutic purposes. With many years of experience, the company has established itself as a leader in the field and is committed to meeting the unique requirements of each client. Headquartered in Sunnyvale, California, Antibody Solutions offers a wide range of products and services to support scientific advancements in various industries.

Tags

Other Diseases

Nervous System Diseases

Monoclonal antibody

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	2

Top 5 Drug Type	Count

Monoclonal antibody	2

Top 5 Target	Count

prolactin	2

AbstractAntigen stimulation of mature B-cells induces activated B-cells followed by differentiation to either memory B-cells or plasmablasts. Each subset has a unique phenotype and potentially unique immunoglobulin repertoire that can be mined for therapeutic antibody candidates. As new targets for therapeutic antibodies have become more challenging, primary B-cell technologies have arisen to meet this challenge, but, their use has typically been limited to one of the B-cell subsets. We sought to develop a platform that could be used generally to interrogate all of the B-cell subsets (i.e., activated, memory and plasmablasts) that are potential sources of useful antibodies. Using fluorescence activated cell sorting (FACS), we have identified and sorted antigen-specific activated and memory B-cells by staining for CD19, surface IgG, and fluorochrome-tagged antigen. Antigen-specific plasmablasts have been identified and sorted after encapsulation of cells in microdroplets, capture of secreted IgG, CD19/CD138 staining, and fluorochrome-tagged antigen staining. Additionally, hybridomas have been evaluated using either protocol. The sorted cells have been sequenced by next generation sequencing (NGS) of paired heavy and light chains. With this platform ~10,000–20,000 antigen specific B-cells from a population of a few million viable lymphocytes have been sorted in 1–2 hours. From the sorted population, 100 – 700 unique paired clonotypes have been identified using this platform. The platform enables the capture of immunoglobulin repertoires from multiple B-cell subsets that is comprehensive, flexible, and cost-effective.

A new cytofluorometric technique for analyzing and isolating antibody-secreting cells: the secretion capture report web

Author: Moisset, Anne ; Kenney, John S. ; Muller, Christian D.

A new cytofluorometric technique is described which enables the simultaneous anal. and isolation of individual members of a B-cell repertoire.The steps for building and analyzing the secretion capture report web (SCRW) are described, the the methodol., strategy, and advantages of using the SCRW to generate hybridoma repertoires are described.

100 Deals associated with Antibody Solutions, Inc.

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100 Translational Medicine associated with Antibody Solutions, Inc.

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Pipeline

Pipeline Snapshot as of 24 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

2

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