Investigating the effect of cold atmospheric argon plasma compared to standard placebo treatment in improving the surface and depth and reducing the wound bacterial load and duration in patients with diabetic foot ulcers

Start Date22 Sep 2024

Sponsor / Collaborator

Yazd University

[+1]

IRCT20170522034081N4

/ CompletedNot ApplicableIIT

The effectiveness of teaching safe attachment to God with an Islamic approach on heart physiology in cardiac patients admitted to Afshar Hospital in Yazd

Start Date23 Aug 2023

Sponsor / Collaborator

Yazd University

IRCT20180827040887N2

/ CompletedPhase 3IIT

The Effect of 8 Weeks Modified FIFA 11+ Training on Functional Factors and Prevalence of Injuries in Male Beach Soccer Players at Premier Country League

Start Date08 Jul 2019

Sponsor / Collaborator

Yazd University

100 Clinical Results associated with Yazd University

0 Patents (Medical) associated with Yazd University

9,072

Literatures (Medical) associated with Yazd University

01 Dec 2025·Molecular Biology Reports

Identification of rare and pathogenic TAL2 gene mutations in B-lineage acute lymphoblastic leukemia (B-ALL) using mutational screening and comprehensive bioinformatics analysis

Article

Author: Heidari, Mohammad Mehdi ; Khormizi, Fateme Zare ; Khanjarpanah, Zohre ; Saadi, Hediye Fahandezh ; Tabrizi, Fateme ; Hashemi, Azam ; Khatami, Mehri

BACKGROUNDRecent genomic research has identified several genetic factors contributing to B-cell acute lymphoblastic leukemia (B-ALL). However, the exact cause of the disease is still not fully understood. It is known that mutations in the TAL2 gene play important roles in the development of acute lymphoblastic leukemia. This study aimed to analyze the molecular and computational profile of the TAL2 mutations in a group of Iranian B-ALL patients for the first time.METHODS AND RESULTSIn this study, 188 patients were enrolled, and the TAL2 gene was sequenced to identify gene variations. The study included structural/functional analysis, homology modeling, molecular docking, and molecular dynamics (MD) simulations to assess the potential impact of the missense mutations on the protein's structure. Three nucleotide variations in the exon, three variations in the 3'UTR, and one deletion variant in the 3'UTR were detected in patients. Through in-silico analysis, it was found that the p. Asp35Glu missense mutation is located in the bHLH domain of the TAL2 protein. Also, the structural and functional analyses predicted that this mutation is a pathogenic or likely pathogenic variant in B-ALL patients. Moreover, a multiple nucleotide deletion (g.659_668del) was found in the 3'UTR in most patients. This deletion occurs at the site of poly-A tail attachment and appears to have significant implications.CONCLUSIONSThese findings offer new insights into the impact of genetic variants in the TAL2 gene on the development of B-ALL and their potential role as tumor biomarkers for the B-ALL. Further research is needed to explore the relationship between specific TAL2 mutations and the clinical presentation of B-ALL.

01 Apr 2025·Radiation Physics and Chemistry

Preparation and structural characterization of PbO and WO3-PVC hybrid nanocomposites for gamma-ray radiation shielding

Author: Zare, Hakimeh ; Eslami-Kalantari, Mohammad ; Ramazani-MoghaddamArani, Ahmad ; Yazdani-Darki, Sepideh

This study has been devoted to investigating the radiation shielding performance of Poly(vinyl chloride)-based nanostructures lead oxide (PbO) and tungsten oxide (WO₃) reinforced composites.The SEM (SEM) images depicted the particle size and morphol. of nanostructures such as PbO nanorods and WO₃ nanoparticles.X-ray diffraction (XRD) results demonstrated a successful fabrication of a hybrid nanocomposite.The gamma-ray spectroscopy experiments have been carried out using a NaI(Tl) scintillation detector and Cs-137, Co- 60, and AM-241 sources and X-ray.The different weight percentages of each by mass were 5, 10, 20, 30, and 40 wt %, of mixed composite (35, 30, 20, 10, 5 wt % WO₃ + 5, 10, 20, 30, 35 wt % PbO).The mass attenuation coefficients of the investigated composites were measured as a function of gamma-ray energies and X-rays utilizing standard radioactive sources.Increasing the PbO or WO₃ nanostructures′ weight percentages in the nanocomposites leads to increased radiation attenuation.Based on the results, the best radiation attenuation, the optimal half-value layer, the tenth value layer, and the mean free path were for PVC/WO₃ 5% + 35% PbO and PVC/WO₃ 10% + 30% PbO hybrid nanocomposite for Am-241, Cs-137, Co-60, and X-ray that replaced hybrid nanocomposite PVC/PbO 40%.

01 Apr 2025·Tissue and Cell

Mandibular bone defect healing using polylactic acid–nano-hydroxyapatite–gelatin scaffold loaded with hesperidin and dental pulp stem cells in rat

Article

Author: Daneshi, Seyyed Sajad ; Mussin, Nadiar M ; Zare, Shahrokh ; Iraji, Aida ; Kurmanalina, Madina A ; Asadi-Yousefabad, Seyedeh-Leili ; Nowzari, Fariborz ; Mokhtarzadegan, Mohamad ; Ebrahimi, Reyhaneh ; Aliabadi, Ehsan ; Khosronejad, Arya ; Arabion, Hamidreza ; Akbarizadeh, Fatemeh ; Amiri, Mohammad Amin ; Tanideh, Nader ; Abbaspour, Shekofeh ; Zarei, Moein ; Tamadon, Amin

Addressing mandibular defects poses a significant challenge in maxillofacial surgery. Recent advancements have led to the development of various biomimetic composite scaffolds aimed at facilitating mandibular defect reconstruction. This study aimed to assess the regenerative potential of a novel composite scaffold consisting of polylactic acid (PLA), hydroxyapatite nanoparticles (n-HA), gelatin, hesperidin, and human dental pulp stem cells (DPSCs) in a rat model of mandibular bone defect. The PLA-HA-GLA composite was synthesized using solvent casting-leaching and freeze-drying methods and subsequently treated with 11 mg of hesperidin. The physicochemical properties of the PLA-HA-GLA and PLA-HA-GLA-HIS composites were analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and thermal gravimetric analysis (TGA). Additionally, the mechanical properties and cytotoxicity of DPSCs were assessed. Subsequently, PLA-HA-GLA and PLA-HA-GLA-HIS scaffolds with or without DPSCs were implanted into mandibular bone defects in rats, followed by histopathological, histomorphometric, and cone-beam computed tomography (CBCT) evaluations after eight weeks. SEM analysis revealed the porous structure of the fabricated PLA-HA-GLA and PLA-HA-GLA-HIS composites without aggregation. FTIR and XRD analyses confirmed the presence of functional groups and elements associated with PLA, HA, GLA, and hesperidin in the composites. Although the PLA-HA-GLA-HIS composite exhibited good thermal stability, its mechanical properties decreased after the addition of hesperidin. The cell viability of DPSCs on the surface of the PLA-HA-GLA-HIS scaffolds was statistically significant compared to that of the control group. Furthermore, histopathological, histomorphometric, and radiological evaluations demonstrated that the implantation of the DPSC-loaded PLA-HA-GLA-HIS scaffold had a beneficial effect on bone tissue reconstruction in rats with mandibular defects. These findings highlight the potential of DPSC-loaded PLA-HA-GLA-HIS composite scaffolds for spongy bone tissue engineering and mandibular defect repair.

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100 Translational Medicine associated with Yazd University

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