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Disease Domain	Count

Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	1

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Tubulin	1

Periodontitis has been linked to systemic inflammation, however research on its role in causing systemic diseases remains limited. Recent studies explore probiotics for microbiome modulation and enhancing natural compound bioavailability. This study investigated periodontitis-related systemic disease mechanisms, and evaluated the mitigation effects of bioconversion product using Lactiplantibacillus plantarum SMFM2016-RK and Artemisia herba-alba extracts. Four types of bioconverted milk [BM1 (L. plantarum SMFM2016-RK), BM2 (BM1 + A. herba-alba ethanol extract), BM3 (BM1 + A. herba-alba hot-water extract), and BM4 (BM1+ both A. herba-alba extracts)] were studied in a periodontitis-induced rat model. Rats were divided into six groups: normal control, skim milk with ligature, and four BM groups with ligature. Periodontitis induction elevated trabecular resorption (0.325 ± 0.057 mm³) and histopathological symptoms. Serum ALT (55.6 ± 6.6 U/L), glucose (261.7 ± 64.3 mg/dL), insulin (1.90 ± 0.87 ng/mL), inflammation in the liver and colon, and gluconeogenesis-related enzyme expression increased. Periodontitis-induced rats showed gut dysbiosis, with decreased Lactobacillaceae level and increased Oscillospiraceae level. BM3 administration significantly reduced the serum glucose (190.9 ± 27.8 mg/dL), ALT (40.5 ± 5.0 U/L), inflammation, and gluconeogenesis-related enzymes, while increasing tight junction proteins expression and phylum Actinobacteria levels in the gut microbiome. The findings highlight the systemic impact of periodontitis on inflammation, glycemic control, and gut microbiome balance. BM3 effectively alleviated these effects suggesting therapeutic potential.

01 Sep 2025·Polymer Degradation and Stability

Sustainable, degradable and malleable low-dielectric-constant thermosets derived from biomass for recyclable green electronics

Author: Lee, Churl Seung ; Lim, Ka Hyun ; Yoo, Myong Jae ; Lee, Youngmin ; Jeong, Soo Jeong ; Lim, Ho Sun ; Kang, Kitae ; Joo, Ji Won

In view of their excellent thermal and chem. resistance, favorable adhesion properties, high tensile strength, and other advantages, epoxy thermosets have numerous industrial applications such as coating, adhesive, and composite material productionHowever, bisphenol A (BPA)-based resins, which account for a significant fraction of the above thermosets, adversely affect human health by interfering with the normal functioning of the endocrine system and cannot be easily decomposed and recycled.Herein, degradable and sustainable bio-based epoxy thermosets with crosslinked network structures are prepared by the epoxidation of isosorbide with epichlorohydrin and the curing of the produced isosorbide diglycidyl ether (ISDGE) with cyclic lactones through a cationic ring-opening reaction.The ISDGE thermosets fully decompose into soluble and recyclable products under mildly basic conditions within three days, which is ascribed to the presence of ester moieties within the polymer network structure.Compared to a representative BPA-based epoxy, ISDGE-based thermosets exhibit lower dielec. constants and are more flexible.Moreover, the glass fibers in ISDGE-based prepregs can be fully recovered after on-demand degradationThus, our work provides promising eco-friendly alternatives to conventional epoxy thermosets and paves the way for the reduction of plastic waste generation and the development of recyclable green electronics.

01 Aug 2025·Sensors and Actuators B: Chemical

A dual-responsive fluorescent probe for cancer diagnostics via simultaneous detection of H2S and hNQO1

Author: Ko, Yeonjin ; Song, Yeonju ; Jung, Cheulhee ; Cha, Yujin ; Lee, Min Hee

Cancer biomarkers, including hydrogen sulfide (H₂S) and human NAD(P)H quinone oxidoreductase-1 (hNQO1), are critical indicators of tumor presence and progression, offering valuable insights for diagnosis, prognosis, and treatment response.H₂S, a gasotransmitter that is overexpressed in various cancers, promotes tumor progression and metastasis, while hNQO1, an enzyme involved in cellular redox balance, is upregulated in multiple cancers and associated with poor patient outcomes.Here, we report the development of a novel dual-responsive fluorescent probe, azide-coumarin-trimethyl lock quinone (ACT), designed to selectively detect both H₂S and hNQO1 activity in live cells.ACT remains minimally fluorescent under physiol. conditions but exhibits a strong fluorescence upon co-recognition of H₂S and hNQO1.This dual-targeting probe enables the distinction between cancerous and normal cells, underscoring its potential as a sensitive and selective diagnostic tool for cancers characterized by the co-overexpression of these biomarkers.

100 Deals associated with Sookmyung Women's University

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100 Translational Medicine associated with Sookmyung Women's University

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Pipeline

Pipeline Snapshot as of 13 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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