Delving into the Latest Updates on Technische Universität Darmstadt with Synapse

Overview

Tags

Neoplasms

Nervous System Diseases

Other Diseases

Small molecule drug

Biological products

Non-degrading molecular glue

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	5
Nervous System Diseases	2
Immune System Diseases	1
Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Small molecule drug	3
Non-degrading molecular glue	1
Trispecific killer cell engager (TriKE)	1
Biological products	1

Top 5 Target	Count

CD16a x EGFR x PDL1	1
FKBP1A x mTOR	1
FKBPs(FKBP prolyl isomerases)	1
EGFR x MerTK	1
GSK-3α(glycogen synthase kinase 3 alpha)	1

Abstract: The transition to sustainable hydrogen and carbon economies is essential for addressing critical global issues such as climate change, resource depletion, and waste management.A vital strategy for low-carbon sustainability in the energy and chem. sectors is the chem. conversion of greenhouse gas into fuels and platform chems.Effective waste management, including waste-to-energy conversion and recycling, plays a crucial role in reducing emissions and promoting a circular economy.A key aspect of this transition is the development of innovative technologies that can transform waste into valuable resources while minimizing environmental impacts.Plasma-based recycling presents a promising solution, offering remarkable versatility for applications like waste upcycling and greenhouse gas conversion.These processes play a crucial role in advancing the development of sustainable carbon and hydrogen economies.

01 Aug 2025·Nuclear Physics A

Dilepton measurements with HADES as probes of hot and dense hadronic matter

Author: Schild, Niklas

Dileptons are an excellent probe to investigate strong-interaction matter under extreme conditions.Their penetrating and virtual nature not only enables invariant measurements, unbiased by the collective expansion of the fireball, but also an insight to the microscopic structure of the dense matter.The High-Acceptance-Di-Electron-Spectrometer (HADES) at GSI, Darmstadt, is uniquely equipped to record and detect these rare probes.Over the last years, it has measured virtual photons, via the di-electron channel, in heavy-ion collisions as well as proton and pion-induced reactions off protons with beam energies of a few GeV per nucleon.Here, we will give a short overview and status update of interesting dilepton observables studied at HADES, including fireball temperature and collectivity studies in terms of anisotropic and radial flow.

01 Aug 2025·Water Research

Fenton–coagulation process for simultaneous abatement of micropollutants and dissolved organic carbon in treated wastewater

Article

Author: Debusmann, Philipp ; Abdighahroudi, Mohammad Sajjad ; Schumacher, Jochen ; Lutze, Holger V ; Kim, Cheolyong

This study demonstrates the integration of the Fenton reaction into the flocculation process at circumneutral pH (6-7), offering a practical approach for simultaneous micropollutant and organic matter removal in wastewater treatment. Unlike conventional Fenton oxidation, which requires acidic conditions, this approach allows Fe(II) to react with hydrogen peroxide at near-neutral pH, forming Fe(III) flocs that enhance flocculation while also generating reactive species for pollutant degradation. At pH 6, hydroxyl radicals were the dominant oxidants, whereas at pH 7, additional reactive species likely contributed to micropollutant removal. Bisphenol A and benzoic acid were removed by approximately 90% at 1 mM peroxide and 2 mM iron. In addition to micropollutant degradation, the Fenton-coagulation process achieved substantial dissolved organic carbon (DOC) removal, which was not observed with Fenton oxidation alone or ozonation. DOC removal was up to 51% in Suwannee River Natural Organic Matter solutions, whereas only 30% of DOC was removed from municipal wastewater effluent, likely due to differences in organic matter composition. These findings highlight the potential of Fenton-coagulation as an effective and scalable treatment strategy for wastewater reuse, improving both pollutant degradation and organic matter removal under practical conditions.

100 Deals associated with Technische Universität Darmstadt

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100 Translational Medicine associated with Technische Universität Darmstadt

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Pipeline

Pipeline Snapshot as of 10 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

5

Preclinical

Other

4

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

FKBP12-mTOR molecular glues(Technical University of Darmstadt) ( FKBP1A x mTOR )	Neoplasms More	Preclinical
GSK-3 inhibitor 27(Technische Universität Darmstadt) ( GSK-3α )	Acute Myeloid Leukemia More	Preclinical
Trispecific NK cell engager(Ferring ) ( CD16a x EGFR x PDL1 )	Neoplasms More	Preclinical
SAFit-2	Huntington Disease More	Preclinical
MerK28-7D9G ( EGFR x MerTK )	Neoplasms More	Preclinical