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Peptide drug conjugates

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ACE(Angiotensin-converting enzyme)	1

An advanced series of bisphenol A-based epoxy resin reinforced with graphitic carbon nitride (g-C₃N₄) nanosheets was fabricated, as robust and super-protective nanocomposite coatings.In this work, a facile solution mixing approach was reported to fabricate epoxy/g-C₃N₄ nanocomposites.A single-step thermal polycondensation method was employed to manifest g-C₃N₄ sheets.The synergistic effects of dispersing various percentages of g-C₃N₄ nanosheets on the mech. robustness and anticorrosion performance of epoxy resin were extensively studied.The structures, sizes, and morphologies of proposed polymeric nanocomposites and nanofillers were investigated using several characterization techniques.The epoxy/g-C₃N₄ nanocomposites were filmed as coating layers using an air-assisted spray technique.The mech. durability was evaluated using impact, T-bending, and cross-hatch test techniques.Electrochem. experiments (in a solution of 3.5 % NaCl) and a salt spray test for 500 h (according to ASTM B-117) were conducted on the coated carbon steel to evaluate the anticorrosion performance.The results indicated that the well-distributed epoxy/g-C₃N₄ (1 wt%) nanocomposite exhibited the highest surface elasticity, mech. durability, and corrosion-resistant properties (R_ct = 428.3 Ω cm² x 10³) with corrosion-inhibition efficiency percentage (_p) of 92.04 %.It exhibited the highest abrasion resistance (very low mg loss for 500 cycles) and outstanding pull-off measurement (12.6 MPa).The salt spray test on the coated carbon steel samples for 500 h showed minimized blister and rusting d. and confirmed the corrosion-prevention of the well-distributed epoxy/g-C₃N₄ nanocomposite.This work offered an insight into the design and preparation of a robust nanocomposite coating material with outstanding anticorrosion properties, and exceptional durability.

01 Aug 2025·Inorganic Chemistry Communications

RSM-CCD optimized adsorptive removal of p-Nitrophenol using Eco-Friendly magnetic activated carbon thin Film

Author: Gabr, Sahar Saad ; El Sayed, Ibrahim El-Tantawy ; Binjawhar, Dalal Nasser ; Fayad, Eman ; Mubarak, Mahmoud F. ; Keshawy, Mohamed ; Moghny, Thanaa Abdel

p-nitrophenol (PNP) is a hazardous pollutant that poses significant risks to human health and ecosystems.This study developed a low-cost magnetic adsorbent, magnetically activated carbon thin film (MACTF) nanocomposite by modifying activated carbon thin film (ACTF) with Fe⁰/Fe₃O₄ nanoparticles for efficient PNP removal.Three nanocomposites (MACTF-1, MACTF-2, and MACTF-3) were synthesized with varying proportions of Fe⁰/Fe₃O₄.Characterization using XRD, TEM, FTIR, Raman, BET, BJH, and TGA confirmed the successful synthesis of the nanocomposites.MACTF-1 exhibited the highest BET surface area (346 m²/g) and total pore volume, making it the most effective adsorbent.The highest PNP removal rate (94 %) was attained under optimized parameters identified through the Response Surface Methodol. (RSM) utilizing the Central Composite Design (CCD) method (pH: 4.5, PNP concentration: 69.5 mg.L^-1, and contact time: 117.9 min).The adsorption process was best described by the Freundlich isotherm (R² = 0.98, X ² = 0.67) and fitted a pseudo-second-order kinetics (R² = 0.99, X ² = 0.09).Thermodn. studies revealed that the adsorption was exothermic (ΔH < 0) and spontaneous (ΔG < 0) in nature.Reusability tests demonstrated that the adsorbent retained approx. 80 % removal efficiency after five consecutive cycles, highlighting its potential for practical applications.The study concludes that MACTF-1 is a highly effective, reusable, and easily separable adsorbent for PNP removal from aqueous environments.

01 Jul 2025·Inorganic Chemistry Communications

Optimization for environmental remediation of direct blue 80 dye using pomegranate peel extract-driven green synthesis of Fe3O4@Cu3(BTC)2

Author: Abd El Salam, Howaida M.

The inclusion of dyes in discharges is an important issue appropriate to their ability to neg. impact living things.An innovative, effortless, and highly efficient technique for developing a magnetic Fe₃O₄@Cu₃(BTC)₂ as a sorbent for removal organic mols. from aqueous solution is evaluated for removal of direct blue 80 (DB80) as a case study.The as-synthesized hybrid nanocomposite was investigated using XRD, FTIR, BET, TEM, XPS, and VSM approaches.The novel adsorbents merge the benefits of MOFs with magnetic nanoparticles, with their great capacity, quick removal and simple solid-phase separation, making them effective sorbents for wastewater treatment.The resulting magnetic Fe₃O₄@ Cu₃(BTC)₂ composites have a superior magnetic response (24.16 emu g^-1), as well as mech. stability, which leads to separation quickly in just a few minutes when predominate to an external magnetic field.At an initial dye concentration of 50 mg/L, contact period of 60 min, and adsorbent content of 5 mg, the maximum adsorption efficiency of 97.21 % for Fe₃O₄@Cu₃(BTC)₂ was achieved, compared to 85.11 % for Cu₃(BTC)₂.Kinetic parameters revealed pseudo-second-order, and adsorption was specified by the Langmuir isotherm where q_e (mg/g) = 92.18 and R² = 0.9997.Addnl., the remarkable reusability of the Fe₃O₄@Cu₃(BTC)₂ adsorption agent, which maintains its effectiveness for at least five consecutive cycles.The effects of adsorbent dosage, contacting time, and pH had the greatest influence on DB80 uptake, according to the statistical anal. conducting using response surface methodol. (RSM).Fe₃O₄@Cu₃(BTC)₂ exhibit potential for treating DB80 in an environmentally friendly way.

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Pipeline

Pipeline Snapshot as of 10 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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