Shanghai HyaMab Biotechnology Co., Ltd., headquartered in Shanghai's Zhangjiang Innovation Cluster Pharmaceutical Valley, is focused on developing new anti-cancer drugs with BIC/FIC potential, such as mAbs and engineered immune cells. The company collaborates with leading international labs and R&D teams including Ruizhi Medicine and the Institute of Immunology at Shanghai University of Science and Technology. The company's strategy is to harness the power of innate immunity, particularly NK cells, to fight the spread of cancer cells.

Disease Domain	Count

Neoplasms	13
Hemic and Lymphatic Diseases	2
Nervous System Diseases	1
Immune System Diseases	1
Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Monoclonal antibody	5
Antibody	3
Cell therapy	3
Bispecific antibody	1
Fusion protein	1

Top 5 Target	Count

CD47(Cluster of differentiation 47)	1
NKp46(Natural cytotoxicity triggering receptor 1)	1
PD-1(Programmed cell death protein 1)	1
4-1BB(Tumor necrosis factor receptor superfamily member 9)	1
4-1BB x EGFRvIII	1

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Pipeline

Pipeline Snapshot as of 30 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

Preclinical

Phase 1

Phase 2

Other

Current Projects

Drug(Targets)	Indications	Global Highest Phase

Recombinant human anti-PD-1 monoclonal antibody(Shanghai Yunyi Health Technology Development Co Ltd) ( PD-1 )	Advanced Malignant Solid Neoplasm More	Phase 1/2
PE-0116 ( 4-1BB )	Advanced Malignant Solid Neoplasm More	Phase 1/2
HY-0102 ( NKG2A )	Solid tumor More	Phase 1
c4D10 ( CD47 )	Neoplasms More	Preclinical
HY000301	Solid tumor More	Discovery

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