Delving into the Latest Updates on Dalian Hissen Bio Pharm, Inc. with Synapse

Overview

Tags

Infectious Diseases

Respiratory Diseases

Digestive System Disorders

Prophylactic vaccine

Genetically engineered subunit vaccine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

No Data

Disease Domain	Count

Infectious Diseases	3

Top 5 Drug Type	Count

Prophylactic vaccine	3
Genetically engineered subunit vaccine	1

Objective: To express recombinant tetanus toxin fragment C (rTTC) in prokaryotic cells, purify the expressed product and determine its activity.Methods: TTC gene fragment was amplified by PCR from the genomic DNA of Clostridium tetani and inserted into vector pThioHisA, and the constructed recombinant plasmid rTTC-pThioHisA was transformed to Escherichia coli BL21 for expression under induction of IPTG.The expressed rTTC protein was purified by ion exchange and gel filtration chromatog., and determined for activity and immunogenicity by Western blot, double immunodiffusion test and immunization of animals.Results: Restriction anal. showed that recombinant plasmid rTTC-pThioHisA was constructed correctly.The expressed rTTC protein existed in both soluble and inclusion body forms and reached a purity of more than 95% after purificationThe purified rTTC protein reacted with the antibody against complete tetanus toxin (TT), while the antibody against rTTC reacted with complete TT.The rTTC induced high immune response in rabbits but low immune response in mice.Conclusion: Recombinant TTC was expressed in prokaryotic cells and purified, which might be used as a novel vaccine against Clostridium tetani and a protein vector of bacterial polysaccharide vaccine.

100 Deals associated with Dalian Hissen Bio Pharm, Inc.

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100 Translational Medicine associated with Dalian Hissen Bio Pharm, Inc.

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Approved

3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Rabies vaccine(Dalian Hissen Bio-Pharmaceutical Co Ltd)	Rabies More	Approved
Influenza vaccine(Dalian Hissen Bio-Pharmaceutical Co Ltd)	Influenza, Human More	Approved
Recombinant hepatitis B vaccine(Dalian Hissen Bio-Pharmaceutical Co Ltd)	Hepatitis B More	Approved