Delving into the Latest Updates on Hefei TG ImmunoPharma Co., Ltd with Synapse

Overview

Tags

Neoplasms

Digestive System Disorders

Skin and Musculoskeletal Diseases

Monoclonal antibody

Bispecific T-cell Engager (BiTE)

T cell engagers (TCE)

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	22
Immune System Diseases	5
Endocrinology and Metabolic Disease	5
Infectious Diseases	4

Top 5 Drug Type	Count

Monoclonal antibody	10
T cell engagers (TCE)	3
Cytokines	2
Trispecific antibody	2
Bispecific antibody	2

Top 5 Target	Count

CD3(T cell surface glycoprotein CD3)	3
IL2RA x PD-1	2
CD112R(Transmembrane protein PVRIG)	2
NCR3LG1(natural killer cell cytotoxicity receptor 3 ligand 1)	2
IL2RA x PD-1 x VEGF	2

This is a Phase 1, multicenter, open-label, two-parts, FIH study to evaluate the tolerability, safety, PK/PD, and preliminary antitumor activity of TGI-5 as monotherapy and in combination with Nivolumab in subjects with unresectable locally advanced/metastatic solid tumors.
The study consists of two parts: TGI-5 monotherapy (Phase 1a: including a dose escalation part and a dose expansion part), TGI-5 in combination with a fixed dose of Nivolumab (Phase 1b: including a dose escalation part and a dose expansion part).

Start Date12 Jun 2025

Sponsor / Collaborator

Hefei TG ImmunoPharma Co., Ltd

[+1]

CTR20251940

/ RecruitingPhase 1

一项在局部晚期/转移性实体瘤受试者中评价TGI-5注射液单药治疗的安全性、耐受性、药代动力学/药效学和抗肿瘤活性的I期研究

[Translation] A Phase I study evaluating the safety, tolerability, pharmacokinetics/pharmacodynamics, and antitumor activity of TGI-5 injection monotherapy in subjects with locally advanced/metastatic solid tumors

主要目的：●确定TGI-5注射液单药治疗在局部晚期/转移性实体瘤受试者中的MTD/OBD。●评价TGI-5注射液单药治疗在局部晚期/转移性实体瘤受试者中的安全性特征。次要目的：●评价TGI-5注射液单药治疗在局部晚期/转移性实体瘤受试者中的PK特征。●评价TGI-5注射液单药治疗在局部晚期/转移性实体瘤受试者中的初步抗肿瘤活性。●表征TGI 5注射液单药治疗在局部晚期/转移性实体瘤受试者中的免疫原性。探索性目的：●评价肿瘤组织中的CD155表达，并探索其与TGI-5注射液抗肿瘤活性和安全性之间的潜在关系。●探索剂量和PK暴露量与效应（包括有效性和/或安全性）之间的关系。

[Translation]

Primary objectives: ● Determine the MTD/OBD of TGI-5 injection monotherapy in subjects with locally advanced/metastatic solid tumors. ● Evaluate the safety profile of TGI-5 injection monotherapy in subjects with locally advanced/metastatic solid tumors. Secondary objectives: ● Evaluate the PK characteristics of TGI-5 injection monotherapy in subjects with locally advanced/metastatic solid tumors. ● Evaluate the preliminary anti-tumor activity of TGI-5 injection monotherapy in subjects with locally advanced/metastatic solid tumors. ● Characterize the immunogenicity of TGI 5 injection monotherapy in subjects with locally advanced/metastatic solid tumors. Exploratory objectives: ● Evaluate CD155 expression in tumor tissues and explore its potential relationship with the anti-tumor activity and safety of TGI-5 injection. ● Explore the relationship between dose and PK exposure and effect (including efficacy and/or safety).

Start Date12 Jun 2025

Sponsor / Collaborator

Hefei TG ImmunoPharma Co., Ltd

NCT06374173

/ RecruitingPhase 1

A Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics/ Pharmacodynamics, and Antitumor Activity of TGI-6 as Monotherapy in Subjects With Locally Advanced/Metastatic Solid Tumors

A Phase 1 Study to Evaluate TGI-6 in Subjects with Locally Advanced/Metastatic Solid Tumors

Start Date03 Jan 2024

Sponsor / Collaborator

Hefei TG ImmunoPharma Co., Ltd

100 Clinical Results associated with Hefei TG ImmunoPharma Co., Ltd

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0 Patents (Medical) associated with Hefei TG ImmunoPharma Co., Ltd

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100 Deals associated with Hefei TG ImmunoPharma Co., Ltd

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100 Translational Medicine associated with Hefei TG ImmunoPharma Co., Ltd

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Pipeline

Pipeline Snapshot as of 05 May 2026

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

13

6

Preclinical

Phase 1

3

9

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

TGI-6 ( CD3 x TAA )	Colorectal Cancer More	Phase 1
TGI-5 ( CD112R )	Hepatocellular Carcinoma More	Phase 1
TGI-2 ( CD112R )	Advanced Malignant Solid Neoplasm More	Phase 1
TGI-14 ( CD3 )	Neoplasms More	Preclinical
TGI-17a ( IL2RA x PD-1 )	Neoplasms More	Preclinical