Delving into the Latest Updates on Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management with Synapse

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Small molecule drug	1

Over 70 million people worldwide suffer from epilepsy, a persistent brain disorder. Although there are more than 20 antiseizure drugs available for the symptomatic treatment of epilepsy, about one-third of patients with epilepsy experience seizures that show resistance to pharmacotherapy. Since patients with drug-resistant epilepsy are more prone to physical injuries, psychosocial dysfunction, early death, and deteriorated life quality, the development of safer and more effective treatments is a crucial clinical need. The gut-brain axis and microbiome research advances have provided new insights into the pathophysiology of epilepsy, the resistance to anti-seizure medicine, and potential treatment targets. Inflammation, disturbance of the blood-brain barrier, and altered neurotransmitters are key pathways linked to gut dysbiosis. The characterization of microbial species and functional pathways has advanced thanks to metagenomic sequencing and high-throughput analysis. In this review, we elaborate on the gut-mediated molecular pathways involved in drug-resistant epilepsy, the gut- modulatory therapeutic options, and their combination with antiseizure medications for drug-resistant epilepsy.

01 Feb 2025·Current Protein & Peptide Science

Comparative Study of Lactogenic Effect and Milk Nutritional Density of Oral Galactagogue in Female Rabbit

Article

Author: Belemkar, Sateesh ; Maru, Saurabh

Background:Hypogalactia and agalactia in lactating mothers are the major causes of child malnutrition, mortality, morbidity, and overall ill health. The development of such treatments requires a well-designed preclinical study with suitable laboratory animals, which needs to be improved. Thus, a suitably designed study with a laboratory animal to analyse galactagogue activity, along with an assessment of the quality and quantity of milk, is required.Objectives:This study aimed to evaluate the potential of rabbits as an animal model for studying lactogenic activity.Methods:The structural homology of prolactin, prolactin, and prolactin in humans, rabbits, and rats was studied using BLAST and PyMol to assess similarity in the lactogenic system. Daily and cumulative milk production and pre-treatment (control) and post-treatment (three drugs) in rabbits were recorded and evaluated by analysing protein, fat, lactose, solid non-fat, and ash values. All parameters were recorded on the 0th day and at the end of weeks 1, 2, and 3. Mammary gland histopathology was performed to evaluate the effects on mammary glands.Results:Homology studies revealed that the sequences of the human and rabbit prolactin genes, receptors, and hormones had a high similarity index. Treatment with Domperidone, Metoclopramide, and Shatavari significantly enhanced milk production by enhancing prolactin secretion; only Shatavari increased milk nutrition. Enlargement of the tubuloalveolar ducts of the mammary glands was observed.Conclusion:Our findings suggest that rabbits are robust, reproducible, ethically superior, and preclinically relevant animals for assessing lactogenic activity.

22 Jan 2025·International Journal of Polymeric Materials and Polymeric Biomaterials

Manipulation of biophysicochemical behavior of transporters using nanodimensional coating

Author: Bajaj, Jay ; Shende, Pravin ; Prabhakar, Bala ; Dholakia, Jheel

A review.Nanocoating is a layer or coating on various drug delivery systems and medical devices within the nanometer range to improve the physicochem. properties, stability, compatibility and protect the materials from the external environment.The categories of materials used for the coating include polymers, metals, and carbon compoundsThe technol. is used for pharmaceutical as well as non-pharmaceutical areas.Nanocoating possesses some disadvantages and the need to use specialized instruments.Nanotechnol. is beneficial from the developmental stages of the formulations to the finalized products and is one of the important methods to improve the efficiency of pharmaceutical products.

100 Deals associated with Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management

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100 Translational Medicine associated with Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management

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Pipeline

Pipeline Snapshot as of 07 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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