The method of quality control of curcumin in Shibaweiheziliniao pills by RP-HPLC was established.A C18 column was used with a mobile phase consisted of mixture of acetonitrile-4% glacial acetic acid (48:52) at flow rate of 0.8 mL/min-1.And the UV detector wavelength was 430 nm.The linear range of curcumin was 0.01-0.20 μg (r = 0.9999).The average recovery was 99.08% (RSD = 1.44%, n = 6).This method is accurate, simple and rapid, and can be used in quality control of Shibaweiheziliniao pills.