Hubei Minkang Pharmaceutical Group Co., Ltd.

Primary objective: To evaluate the bioequivalence of the two preparations in healthy Chinese subjects in the fasting and fed state, using the eltrombopag ethanolamine suspension (trade name: Revolade®, specification: 25 mg (calculated in C25H22N4O4)) of Novartis Europharm Limited as the reference preparation and the eltrombopag ethanolamine suspension (25 mg (calculated in C25H22N4O4)) developed by Hubei Minkang Pharmaceutical Group Co., Ltd. as the test preparation. Secondary objective: To observe the safety of the test preparation and the reference preparation in healthy Chinese subjects.

Main purpose: Using the licensee Anacor Pharmaceuticals, Inc.'s crisaborole ointment (2%, trade name Staquis) as the reference preparation and the Hubei Minkang Pharmaceutical Group Co., Ltd.'s crisaborole ointment (2%) as the test preparation, a single-center, randomized, open, single-dose, two-preparation, two-cycle, two-sequence, crossover clinical trial was conducted to evaluate the bioequivalence of the two preparations under topical conditions in Chinese healthy subjects. Secondary objectives: 1) To evaluate the safety of the test preparation and the reference preparation in Chinese healthy subjects; 2) To evaluate the skin reactivity of the test preparation and the reference preparation in Chinese healthy subjects.

Main purpose: Using the nalfuraphine hydrochloride orally disintegrating tablets (trade name: Remitch OD Tablets, specification: 2.5 μg) of Tori Co., Ltd. as the reference preparation, and using the drug developed by Hubei Minkang Pharmaceutical Group Co., Ltd. Nafuraphine hydrochloride orally disintegrating tablets are the test preparations. A single-center, randomized, open-label, single-dose, two-preparation, two-cycle, two-sequence, crossover design clinical trial was conducted to evaluate the two preparations in healthy subjects in China. Bioequivalence in fasted and postprandial states. Secondary purpose: To observe the safety of the test preparation and reference preparation in Chinese healthy subjects.