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Infectious Diseases

Other Diseases

Nervous System Diseases

Prophylactic vaccine

Conjugated vaccine

Combination vaccine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	18
Nervous System Diseases	4

Top 5 Drug Type	Count

Prophylactic vaccine	17
Conjugated vaccine	4
Combination vaccine	4
Live attenuated vaccine	2
Monoclonal antibody	1

Top 5 Target	Count

RABV-G	1

Objective: This study aimed to explore the usefulness of the peripheral blood eosinophil count (PBEC) in assessing the level of fractional exhaled nitric oxide (FeNO) and predicting bronchodilation test results. Methods: We retrospectively analyzed the data of 384 outpatients who underwent FeNO measurement at our Department of Respiratory and Critical Care Medicine from March to June 2019. The FeNO level was compared among different PBECs to explore the association among them. Furthermore, the sensitivity and specificity of PBECs in predicting bronchodilation test results were assessed by using receiver operating characteristic (ROC) curve analysis. Results: There was a moderate correlation between PBECs and FeNO levels (r = 0.414; p < 0.05). In the subjects with PBECs ≥ 0.3 × 109/L, the median FeNO level was 39 ppb (interquartile range, 22.5‐65.5 ppb), significantly higher than in the subjects with PBECs < 0.3 × 109/L. The area under the ROC curve was 0.707 (p < 0.05). The maximum Youden index (0.348) was at PBECs = 0.205 × 109/L, which achieved sensitivity and specificity of 63% and 71.8%, respectively. Conclusion: PBECs ≥ 0.3 × 109/L can predict a positive bronchodilation test result and a high FeNO level, with a probability of 50% in the subjects with chronic cough and shortness of breath; in the absence of corresponding symptoms and a low PBEC, the predictive value was small. For hospitals not able to conduct FeNO measurements, for outpatients with poor economic conditions, and for patients with confirmed or suspected novel coronavirus disease 2019, the PBEC, in conjunction with a patient's clinical symptoms, can improve the diagnostic accuracy of allergic asthma and assessment of airway inflammation while reducing the risk of infection.

01 Sep 2018·Experimental Cell ResearchQ3 · MEDICINE

Staphylococcal enterotoxin C2 stimulated the maturation of bone marrow derived dendritic cells via TLR-NFκB signaling pathway

Q3 · MEDICINE

Article

Author: Zhou, Libao ; Xu, Mingkai ; Liao, Hui ; Zhang, Chenggang ; Li, Yansheng ; Zhang, Huiwen ; Yao, Songyuan

As a kind of superantigen, staphylococcal enterotoxin C2 (SEC2) is well known as a powerful immunomodulator. However, most previous studies about SEC2 focus on its T cell activating characters. But the direct effect of SEC2 on antigen-presenting cells (APCs) which are important for the T cell activation is not clearly. In this study, we investigated the effect of SEC2 on murine bone marrow-derived dendritic cells (BMDCs) which are known as the specialized professional APCs. Contrary to its effects on T cells, SEC2 could not induce proliferation or cytotoxicity to BMDCs even in high concentrations. While SEC2 could promote the mature of BMDCs with increased expression of co-stimulatory molecules on cell membrane such as CD80, CD86, and MHC II. The production of pro-inflammatory cytokines such as TNF-α, IFN-γ and IL-6 were also increased in BMDCs treated with SEC2. We also found that SEC2 enhanced the genes expression of pattern recognition receptors including toll-like receptors 2 (TLR2) and TLR4 in BMDCs, and up-regulated the key signal molecule MyD88 in both mRNA and protein levels. In addition, SEC2 also caused IκBα degradating and NFκB p65 translocating from the cytoplasm to the nucleus in BMDCs. The siRNAs for both TLR2 and TLR4, as well as NFκB specific inhibitor BAY 11-7085 could inhibit the co-stimulatory molecules expression and pro-inflammatory cytokines releasing induced by SEC2. Moreover, TLR2/4 specific siRNAs inhibited p65 and MyD88 upregulation induced by SEC2. In summary, all our results indicated that SEC2 could stimulate BMDCs maturation through TLR-NFκB signaling pathways.

01 Nov 2014·Phytochemical AnalysisQ2 · BIOLOGY

Rapid Determination of Flavonoids from Portulaca Oleracea L

Q2 · BIOLOGY

Article

Author: Zhang, Qingyi ; Song, Shaojiang ; Gao, Pinyi ; Li, Danqi ; Wu, Yingying ; Tian, Jinlong ; Li, Lingzhi ; Liang, Xiao

INTRODUCTIONPortulaca oleracea L. (P. oleracea, purslane) is an edible plant that is widely distributed around the world, and flavonoids are its main bioactive constituents. Therefore, the detection of flavonoids is very important for a better understanding of its pharmacological actions and to monitor the product quality control of P. oleracea.OBJECTIVETo develop a rapid method to extract and determine 26 bioflavonoids in P. oleracea, based on microwave extraction (MWE) and triple quadrupole-linear ion trap mass spectrometry.METHODSThe optimal conditions of MWE for the extraction of flavonoids from P. oleracea involved the use of methanol as the extraction solvent, a microwave power of 300 W, an extraction time of 450 s, and a solvent-to-solid ratio of 30 mL/g. The samples were analysed using an ultra-performance liquid chromatograph coupled with a triple quadrupole-linear ion trap mass spectrometer (UPLC-MS/MS) system.RESULTSThe calibration curves of all 26 analytes showed good linearity (r ≥ 0.999) and the intra- and interday precisions and repeatability were all within required limits. The mean recoveries measured at three concentrations were higher than 94.2%, with RSDs lower than 2.94% for the targets.CONCLUSIONThe established MWE/UPLC-MS/MS method is a rapid and effective method for quality evaluation of P. oleracea from different production regions and different harvest periods.

100 Deals associated with Liaoning Chengda Biotechnology Co. Ltd.

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100 Translational Medicine associated with Liaoning Chengda Biotechnology Co. Ltd.

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Pipeline

Pipeline Snapshot as of 24 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

10

1

IND Approval

Phase 1 Clinical

5

1

Phase 3 Clinical

NDA/BLA

1

2

Approved

Other

4

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Rabies Vaccine for Human Use (Chengda Bio)	Rabies More	Approved
Japanese Encephalitis Vaccine (Vero cell),Inactivated (Chengda Bio)	Encephalitis, Japanese More	Approved
Rabies vaccine (Chengda Biology)	-	NDA/BLA
Tetravalent influenza vaccine (Chengda Bio)	Influenza, Human More	Phase 3
Recombinant Fifteen Valent Human Papillomavirus Vaccine(E.coli)(Liaoning Chengda Biotechnology)	Human Papillomavirus Infection More	Phase 1