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Small molecule drug	1

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Nav1.2 x PI4Ks x SIRT1 x hERG x nAChRα9&α10	1

CONTEXTWDJ-S4, a standardized herbal formula, has been prescribed for refractory functional dyspepsia (FD) in Korea, but the detailed mechanisms are lacking.OBJECTIVEThe present study investigates the acceleration of gastrointestinal (GI) motility by WDJ-S4 and its potential mechanisms.MATERIALS AND METHODSFor five days, WDJ-S4 (50, 100 and 200 mg/kg) or mosapride (3 mg/kg) was orally given to BALB/c mice. After 20 h of fasting, loperamide (10 mg/kg, i.p.) was given to the mice except for normal group. To assess gastric emptying or intestinal propulsion, 500 μL of 0.05% phenol red or 200 μL of 5% charcoal diet was given once orally.RESULTSLoperamide delayed gastric emptying and intestinal propulsion, while WDJ-S4 ameliorated peristaltic dysfunction, evidenced by reductions of remaining phenol red in the stomach and a marked increase of charcoal propulsion in the intestine. WDJ-S4 also normalized levels of acetylcholine and acetylcholine-related enzymes, including choline acetyltransferase (ChAT) and acetylcholinesterase (AChE), in the gastric antrum and jejunum. C-kit level and smooth muscle contraction-related genes were elevated by WDJ-S4 in both the gastric antrum and jejunum.CONCLUSIONOverall, WDJ-S4 can effectively promote GI motility. The efficacy is associated with modulation of acetylcholine pathway and the interstitial cells of Cajal (ICCs) activation. All the results provide scientific evidence supporting the clinical usage of WDJ-S4 for FD.

01 Jun 2025·Integrative Medicine Research

Integrative medicine and perinatal outcomes among women giving birth: A national population-based study in South Korea

Article

Author: Park, Sunju ; Kim, Seongju ; Lee, Hye Won ; Choi, Jiae

BackgroundThe aim of this study was to examine the effects of integrative medicine (IM) on perinatal outcomes and health care utilization in women who gave birth in Korea.MethodsThis study used National Health Insurance Sharing Service (NHISS) claims data and established a retrospective cohort of all women who gave birth in Korea from January to December 2021. The women were categorized into IM and conventional medicine (CM) groups according to the nature of their health institution visits before delivery. To assess the risk of adverse perinatal outcomes between the two groups, a logistic regression model was used to estimate the odds ratio (OR) and the corresponding 95 % confidence interval (CI).ResultsA total of 171,136 women were divided into the IM (n = 91,902) and CM (n = 79,234) groups. Among the 9,608,545 claims analyzed, respiratory system disease was the most common primary diagnosis, followed by genitourinary system diseases. In the IM group, 19,153 claims were associated with infertility diagnosis codes, with the most frequent primary diagnoses being female infertility associated with anovulation and female infertility of other origins. Compared with the CM group, the IM group had significantly greater rates of assisted reproductive technology (ART) use (aOR, 1.25 [95 % CI, 1.21, 1.29]; P < 0.0001) and cesarean delivery (aOR, 1.08 [95 % CI, 1.06, 1.11]; P < 0.0001).ConclusionThe study findings support that dual health care system use is not associated with the health outcomes of women who gave birth. The findings are expected to be valuable for establishing national health and medical policies or promoting health care utilization for women who give birth in South Korea.

01 Apr 2025·Journal of Burn Care & Research

941 Needs Analysis for the Development of a Hospital-Based Trauma Treatment Protocol for Firefighters

Author: Lee, Jeong-Eun ; Hwang, Se Hee ; Hur, Mira

AbstractIntroductionThis study aims to provide foundational data for developing a hospital-based trauma treatment protocol for firefighters by analyzing the perceptions, treatment experiences, self-care practices, and trauma-related needs of 1,057 Seoul firefighters.MethodsThis study collected a total of 1,061 responses through an on-site survey of firefighters who participated in the ‘2023 Seoul Safety Festival’ from May 11 to 13, 2023, and an online survey conducted from May 11 to 31. Ultimately, data from 1,057 firefighters in Seoul, excluding 4 firefighters working outside of Seoul, were used for the analysis.ResultsThe results show that 96.31% of respondents recognized a high risk of trauma, such as PTSD, due to the nature of their job, and 45.13% reported experiencing trauma related to their firefighting duties. However, only 25.79% had received professional treatment. Additionally, 55.53% expressed a willingness to participate in intensive treatment programs, and 83.54% of respondents indicated a need for tailored treatment interventions specific to firefighters. These respondents preferred personalized treatment involving mental health specialists, with a duration of 3 to 6 months.ConclusionsThis study provides important recommendations for developing treatment programs that reflect the trauma experiences and perceptions of firefighters, and it is expected to contribute to improving their mental health and well-being.Applicability of Research to PracticeThe results of this study emphasize the need for the development of a trauma treatment program optimized for firefighters and an institutional environment to support it, and are significant in providing basic data for effective interventions in the mental health management and trauma treatment of firefighters in the future.Funding for the StudyN/A

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Pipeline

Pipeline Snapshot as of 10 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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