Shan Dong Cheng Kang Yao Ye You Xian Gong Si

Main study objectives To study the pharmacokinetics of the test preparation metformin hydrochloride sustained-release tablets (specification: 0.5g, produced by Yiling Wanzhou International Pharmaceutical Co., Ltd.) and the reference preparation metformin hydrochloride sustained-release tablets (trade name: Glucophage®, specification: 0.5g, produced by Merck Pharmaceuticals (Jiangsu) Co., Ltd.) in healthy adult subjects after a single oral administration in the fasting and postprandial state, and to evaluate the bioequivalence of the two preparations. Secondary study objectives To evaluate the safety of the test preparation metformin hydrochloride sustained-release tablets and the reference preparation metformin hydrochloride sustained-release tablets (Glucophage®) after a single oral administration in healthy subjects after fasting and postprandial state.