The prescription and economics and quality control methods of cetirizine hydrochloride orally disintegrating tablets were described. Methods: In this study, the formulation of cetirizine hydrochloride orally disintegrating tablets was studied, and the preparation process of preparing wet granules, drying, granulating and tableting was carried out, and the disintegrating agent and foam were used. The advantages of the agent, and the quality of the disintegration time limit, friability, dissolution, content and other items of the orally disintegrating tablet were tested. Results: The test results of disintegration time, brittleness, dissolution and content of the orally disintegrating tablets prepared by the formulation were in compliance with the standard requirements, and the orally disintegrating tablets of the prescription also had a good taste and tablets. The shape was complete, the hardness was moderate, and it was not easy to break. Conclusion: The experiment proves that the cetirizine hydrochloride orally disintegrating tablet prepared by the formulation has stable and controllable quality, and the preparation process is simple and convenient for mass production