Shandong Fangming Pharmaceutical Stock Co. Ltd.

The quality and stability of Vitamin C Tablets prepared by different prescriptions were compared for bolting the optimal prescription and preparation method for preparing high-quality Vitamin C Tablets.Using pregelatinized starch-lactose (5:4) as the diluent, supplemented with tartaric acid or/and different antioxidants to improve the stability of tablets and starch, and using ethanol solution and polyvinylpyrrolidone K30 dilute alc. solution as binder, Vitamin C Tablets were prepared by ordinary wet granulation method.Prescription screening was adopted by designing different prescriptions and then acceleration and long-term stability were studied with the listed packaging.Vitamin C Tablets prepared by using tartaric acid and glutathione as antioxidant, dilute alc. solution of polyvinylpyrrolidone K30 as binder had best quality.The characters, content and disintegration time after acceleration for six month and 24 mo of stability investigation had no significant change and the quality was stable.Vitamin C Tablets prepared by the screened prescription met the design requirements and was suitable for clin. application.