Delving into the Latest Updates on Purapharm (Nanning) Pharmaceuticals Co., Ltd. with Synapse

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Digestive System Disorders

Herbal medicine

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Herbal medicine	1

An automated headspace solvent free microextraction (HS-SFME) based gas chromatography/mass spectrometry (GC/MS) was developed for discrimination of Radix Angelica sinensis (RAS) from different cultivation regions. The MS data were subjected to principal component analysis (PCA) and hierarchical clustering analysis (HCA) to rapidly find the potential characteristic components of RAS from top-geoherb region and non top-geoherb region. Totally, fifty-one volatile organic compounds (VOCs) were identified, in which β-ocimene, α-pinene, 3-methylbutanal, heptanes, butanal were identified as potential markers for distinguishing RAS from top-geoherb region and non top-geoherb region. Sulphur dioxide was detected in some commercial RAS samples, which implied that sulphur-fumigation might be the main reason for the quality inconsistencies of commercial RAS samples. These results suggested that RAS from top-geoherb region and non-top geoherb region could be discriminated by the method. And characteristic chemical markers found in current study can be used for ensuring consistent quality of top-geoherb of RAS.

Shizhen Guoyi Guoyao

Study of SPE-HPLC-ELSD characteristic spectrum of Astragalus membranaceus

Author: Huang, Li-feng ; Su, Zhi-heng ; Qiu, Li ; Zou, Lu-hui

SPE-HPLC-ELSD characteristic spectrum of Astragalus membranaceus was studied.HPLC-ELSD was performed on Grace Alltima C₁₈ (4.6 mm×250 mm, 5 μm) column, acetonitrile-water as mobile phase, flow rate 0.8 mL/min.HPLC-ELSD characteristic spectrum of Astragalus membranaceus was established.Fourteen peaks were obtained, and structures of 5 peaks were identified.

Medicinal Plant

Simultaneous determination of four phenolic acids in radix salviae miltiorrhizae formula granules by QAMS

Author: Jiang, Zhihong ; Wei, Hongyan ; Lu, Jinguang ; Zhou, Jian ; Yu, Qiongxi ; Song, Jingzheng

[ Objectives] This study aimed to establish a QAMS (quant. anal. of multi-components by single-marker) method for simultaneous determination of four phenolic acids, salvianolic acid B, tanshinol, lithospermic acid and rosmarinic acid in Radix Salviae Miltiorrhizac by HPLC and conduct methodol. investigation.[Methods] Salvianolic acid B, with moderate retention time, good resolution, great response value and easy availability was selected as the internal standard, and the relative retention values and relative correction factors between tanshinol, rosmarinic acid, lithospermic acid and salvianolic acid B were established.The results of QAMS were compared with those of external standard method to verify the accuracy and applicability of QAMS.[ Results] There were no significant differences between the calculated values of QAMS and the measured values of external standard method.The relative deviation was less than 3%, and the relative correction factors obtained from the experiment were credible.[ Conclusions] QAMS can l>e used to determine the contents of phenolic acids in Radix Salviae Miltiorrliizae formula granules.

100 Deals associated with Purapharm (Nanning) Pharmaceuticals Co., Ltd.

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100 Translational Medicine associated with Purapharm (Nanning) Pharmaceuticals Co., Ltd.

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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