Delving into the Latest Updates on Purapharm (Nanning) Pharmaceuticals Co., Ltd. with Synapse

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Herbal medicine	1

An automated headspace solvent free microextraction (HS-SFME) based gas chromatography/mass spectrometry (GC/MS) was developed for discrimination of Radix Angelica sinensis (RAS) from different cultivation regions. The MS data were subjected to principal component analysis (PCA) and hierarchical clustering analysis (HCA) to rapidly find the potential characteristic components of RAS from top-geoherb region and non top-geoherb region. Totally, fifty-one volatile organic compounds (VOCs) were identified, in which β-ocimene, α-pinene, 3-methylbutanal, heptanes, butanal were identified as potential markers for distinguishing RAS from top-geoherb region and non top-geoherb region. Sulphur dioxide was detected in some commercial RAS samples, which implied that sulphur-fumigation might be the main reason for the quality inconsistencies of commercial RAS samples. These results suggested that RAS from top-geoherb region and non-top geoherb region could be discriminated by the method. And characteristic chemical markers found in current study can be used for ensuring consistent quality of top-geoherb of RAS.

Yaowu Fenxi Zazhi

SPE-GC-ECD determination of 21 organochlorine pesticides residue in ginseng

Author: Qiu, Li ; Wen, Qingwei ; Su, Huasheng ; Zhou, Jian

A new method for determination of the residue of 21 organochlorine pesticides (OCPs) in ginseng was established.The samples were extracted by water-acetone (1:2, volume/volume), and then partitioned with n-hexane, resp., the extract was purified by florisil SPE column, and GC-ECD and the dual column were employed to determine the 21 OCPS residue.There were good linear relationships over the range of 0.89-1690 μg/L^-1 for 21 OCPs.The detection limit is between 0.001-2.23 μg/L^-1.The percentage recoveries from the samples (n = 9) at three level was between 85.4-115.4%, RSD was between 11.3-19.0%, resp.The established method is simple, it can be used to determine the 21 OCPs in ginseng.

Medicinal Plant

Identification of HPLC characteristic chromatograms of phenylethanoid glycosides and iridoid glycosides in herba cistanche of different origins

Author: Huang, Yan ; Huang, Xiongmei ; Wei, Hongyan ; Wei, Minling ; Norimoto, Hisayoshi ; Nong, Xinwei

This study aimed to establish a quality evaluation method for Herba Cistanche based on the HPLC characteristic chromatograms of the phenylethanoid glycosides and iridoid glycosides, and compare the HPLC characteristic chromatograms of different origins of Herba Cistanche.The chromatog. conditions used were as follows: column, Agilent ZORBAX Eclipse Plus C18 column (4. 6 mm x 250 mm, 5μm) ; gradient elution, acetonitrile-0.1% phosphoric acid aqueous solution; flow rate, 1.0 mL/min; detection wave length, 240 nm; column temperature, 30°C.Cistanche tubulosa (Schenk) Wight showed 9 characteristic peaks, Cistanche deserticola Y. C. Ma showed 10 characteristic peaks, Cistanche salsa (C. A. Mey.) G. Beck showed 7 characteristic peaks, and Cistanche sinensis G. Beck showed 4 characteristic peaks.Peak 6 was echinacoside, peak 7 was verbascoside, peak 8 was tubuloside A, peak 9 was isoacteoside and peak 10 was cistanoside A.The characteristic chromatograms of the four different origins of Herba Cistanche were significantly different.This characteristic chromatogram method has good reproducibility and can be used to distinguish 4 different origins of Herba Cistanche, C. deserticola Y. C. Ma, C. tubulosa (Schenk) Wight, C. sinensis G. Beck and C. salsa (C. A. Mey.) G. Beck.

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Pipeline

Pipeline Snapshot as of 23 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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